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Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis.
http://hdl.handle.net/10422/00013509
http://hdl.handle.net/10422/00013509e7e5aba3-9dea-4ff2-a190-00723c7bf5fa
名前 / ファイル | ライセンス | アクション |
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tjem.2022.J106 (982.9 kB)
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This article is licensed under a Creative Commons
[Attribution-NonCommercial-NoDerivatives 4.0 International] license. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-BY-NC-ND 4.0). Anyone may download, reuse, copy, reprint, or distribute the article without modifications or adaptations for non-profit purposes if they cite the original authors and source properly. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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tjem.2022.J106_Supplementary (1.1 MB)
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This article is licensed under a Creative Commons
[Attribution-NonCommercial-NoDerivatives 4.0 International] license. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-BY-NC-ND 4.0). Anyone may download, reuse, copy, reprint, or distribute the article without modifications or adaptations for non-profit purposes if they cite the original authors and source properly. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2023-03-08 | |||||
タイトル | ||||||
タイトル | Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | anti-lactoferrin antibody | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | autoimmune disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endometriosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | lactoferrin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neutrophil | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
MORI-YAMANAKA, Kaya
× MORI-YAMANAKA, Kaya× KIMURA, Fuminori× NAKAMURA, Akiko× HANADA, Tetsuro× KITAZAWA, Jun× MORIMUNE, Aina× TSUJI, Shunichiro× MURAKAMI, Takashi |
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著者別名 |
森, 加也
× 森, 加也× 木村, 文則× 中村, 暁子× 花田, 哲郎× 北澤, 純× 森宗, 愛菜× 辻, 俊一郎× 村上, 節 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Endometriosis is a disease that is characterized by the ectopic presence of the endometrium or its similar cells. A high prevalence of patients with autoimmune diseases has been reported among patients with endometriosis although the cause of endometriosis remained unknown. Recently, the anti-lactoferrin antibody is reported to be highly detected in autoimmune diseases. This study focused on lactoferrin and anti-lactoferrin antibodies to explore the pathology of endometriosis. Lactoferrin is a substance that regulates inflammation and is produced by neutrophils. Anti-lactoferrin antibody is a type of perinuclear antineutrophil cytoplasmic antibody. The serum lactoferrin and anti-lactoferrin antibody levels were compared among patients with or without endometriosis, revealing significantly higher levels in patients with endometriosis. Additionally, a decreased serum anti-lactoferrin antibody level was observed after surgical endometriosis resection. The receiver operating characteristic curve analysis determined the reference values for the serum lactoferrin and anti-lactoferrin antibody levels. Patients whose serum level exceeded the reference anti-lactoferrin antibody value were significantly higher in more than 40% of cases in the endometriosis group. The rate is comparable to that of autoimmune diseases. This is the first report that anti-lactoferrin antibody is frequently observed in patients with endometriosis, adding a new perspective to the understanding of the pathology of endometriosis although precisely elucidating the mechanism by which lactoferrin and anti-lactoferrin antibody appear in endometriosis in the future is necessary. | |||||
書誌情報 |
en : The Tohoku journal of experimental medicine 巻 259, 号 2, p. 135-142, 発行日 2023-01-21 |
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出版者 | ||||||
出版者 | Tohoku University Medical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-3329 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 36476585 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1620/tjem.2022.j106 | |||||
関連名称 | 10.1620/tjem.2022.j106 | |||||
権利 | ||||||
権利情報 | © 2023 Tohoku University Medical Press | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |