{"created":"2023-06-19T10:44:03.595244+00:00","id":4432,"links":{},"metadata":{"_buckets":{"deposit":"76f80c96-779d-4487-b2e7-7b15da127850"},"_deposit":{"created_by":11,"id":"4432","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4432"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004432","sets":["30:66:216"]},"author_link":["9274","7753","564","7548","802","7755","7754","798"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-01-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"142","bibliographicPageStart":"135","bibliographicVolumeNumber":"259","bibliographic_titles":[{},{"bibliographic_title":"The Tohoku journal of experimental medicine","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森, 加也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"木村, 文則"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"中村, 暁子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"花田, 哲郎"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"北澤, 純"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"森宗, 愛菜"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"辻, 俊一郎"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"村上, 節"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Endometriosis is a disease that is characterized by the ectopic presence of the endometrium or its similar cells. A high prevalence of patients with autoimmune diseases has been reported among patients with endometriosis although the cause of endometriosis remained unknown. Recently, the anti-lactoferrin antibody is reported to be highly detected in autoimmune diseases. This study focused on lactoferrin and anti-lactoferrin antibodies to explore the pathology of endometriosis. Lactoferrin is a substance that regulates inflammation and is produced by neutrophils. Anti-lactoferrin antibody is a type of perinuclear antineutrophil cytoplasmic antibody. The serum lactoferrin and anti-lactoferrin antibody levels were compared among patients with or without endometriosis, revealing significantly higher levels in patients with endometriosis. Additionally, a decreased serum anti-lactoferrin antibody level was observed after surgical endometriosis resection. The receiver operating characteristic curve analysis determined the reference values for the serum lactoferrin and anti-lactoferrin antibody levels. Patients whose serum level exceeded the reference anti-lactoferrin antibody value were significantly higher in more than 40% of cases in the endometriosis group. The rate is comparable to that of autoimmune diseases. This is the first report that anti-lactoferrin antibody is frequently observed in patients with endometriosis, adding a new perspective to the understanding of the pathology of endometriosis although precisely elucidating the mechanism by which lactoferrin and anti-lactoferrin antibody appear in endometriosis in the future is necessary.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tohoku University Medical Press"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"36476585","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1620/tjem.2022.j106"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1620/tjem.2022.j106","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 Tohoku University Medical Press"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-3329","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MORI-YAMANAKA, Kaya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KIMURA, Fuminori"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Akiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HANADA, Tetsuro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KITAZAWA, Jun"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MORIMUNE, Aina"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TSUJI, Shunichiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MURAKAMI, Takashi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-08"}],"displaytype":"detail","filename":"tjem.2022.J106.pdf","filesize":[{"value":"982.9 kB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons \n[Attribution-NonCommercial-NoDerivatives 4.0 International] license.\nThis is an open-access article distributed under the terms of the Creative Commons \nAttribution-NonCommercial-NoDerivatives 4.0 International License (CC-BY-NC-ND 4.0). \nAnyone may download, reuse, copy, reprint, or distribute the article without modifications or adaptations for non-profit purposes if they cite the original authors and source properly.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"tjem.2022.J106","url":"https://shiga-med.repo.nii.ac.jp/record/4432/files/tjem.2022.J106.pdf"},"version_id":"cf876345-e7c8-4ce1-bb35-59bcec5661dd"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-08"}],"displaytype":"detail","filename":"tjem.2022.J106_Supplementary.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons \n[Attribution-NonCommercial-NoDerivatives 4.0 International] license.\nThis is an open-access article distributed under the terms of the Creative Commons \nAttribution-NonCommercial-NoDerivatives 4.0 International License (CC-BY-NC-ND 4.0). \nAnyone may download, reuse, copy, reprint, or distribute the article without modifications or adaptations for non-profit purposes if they cite the original authors and source properly.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"tjem.2022.J106_Supplementary","url":"https://shiga-med.repo.nii.ac.jp/record/4432/files/tjem.2022.J106_Supplementary.pdf"},"version_id":"a9dc172c-7940-4771-817c-bf543186df4e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anti-lactoferrin antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endometriosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lactoferrin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophil","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis."}]},"item_type_id":"4","owner":"11","path":["216"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-03-08"},"publish_date":"2023-03-08","publish_status":"0","recid":"4432","relation_version_is_last":true,"title":["Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:08:09.266794+00:00"}