@article{oai:shiga-med.repo.nii.ac.jp:00004432,
 author = {森, 加也 and 木村, 文則 and 中村, 暁子 and 花田, 哲郎 and 北澤, 純 and 森宗, 愛菜 and 辻, 俊一郎 and 村上, 節 and MORI-YAMANAKA, Kaya and KIMURA, Fuminori and NAKAMURA, Akiko and HANADA, Tetsuro and KITAZAWA, Jun and MORIMUNE, Aina and TSUJI, Shunichiro and MURAKAMI, Takashi},
 issue = {2},
 journal = {The Tohoku journal of experimental medicine},
 month = {Jan},
 note = {application/pdf, Endometriosis is a disease that is characterized by the ectopic presence of the endometrium or its similar cells. A high prevalence of patients with autoimmune diseases has been reported among patients with endometriosis although the cause of endometriosis remained unknown. Recently, the anti-lactoferrin antibody is reported to be highly detected in autoimmune diseases. This study focused on lactoferrin and anti-lactoferrin antibodies to explore the pathology of endometriosis. Lactoferrin is a substance that regulates inflammation and is produced by neutrophils. Anti-lactoferrin antibody is a type of perinuclear antineutrophil cytoplasmic antibody. The serum lactoferrin and anti-lactoferrin antibody levels were compared among patients with or without endometriosis, revealing significantly higher levels in patients with endometriosis. Additionally, a decreased serum anti-lactoferrin antibody level was observed after surgical endometriosis resection. The receiver operating characteristic curve analysis determined the reference values for the serum lactoferrin and anti-lactoferrin antibody levels. Patients whose serum level exceeded the reference anti-lactoferrin antibody value were significantly higher in more than 40% of cases in the endometriosis group. The rate is comparable to that of autoimmune diseases. This is the first report that anti-lactoferrin antibody is frequently observed in patients with endometriosis, adding a new perspective to the understanding of the pathology of endometriosis although precisely elucidating the mechanism by which lactoferrin and anti-lactoferrin antibody appear in endometriosis in the future is necessary., Journal Article},
 pages = {135--142},
 title = {Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis.},
 volume = {259},
 year = {2023}
}