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  1. 医学科
  2. 産科学婦人科学講座
  3. 学術雑誌掲載論文等(産科学婦人科学講座)

Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis.

http://hdl.handle.net/10422/00013509
http://hdl.handle.net/10422/00013509
e7e5aba3-9dea-4ff2-a190-00723c7bf5fa
名前 / ファイル ライセンス アクション
tjem.2022.J106.pdf tjem.2022.J106 (982.9 kB)
This article is licensed under a Creative Commons
[Attribution-NonCommercial-NoDerivatives 4.0 International] license.
This is an open-access article distributed under the terms of the Creative Commons
Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-BY-NC-ND 4.0).
Anyone may download, reuse, copy, reprint, or distribute the article without modifications or adaptations for non-profit purposes if they cite the original authors and source properly.
https://creativecommons.org/licenses/by-nc-nd/4.0/
tjem.2022.J106_Supplementary.pdf tjem.2022.J106_Supplementary (1.1 MB)
This article is licensed under a Creative Commons
[Attribution-NonCommercial-NoDerivatives 4.0 International] license.
This is an open-access article distributed under the terms of the Creative Commons
Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-BY-NC-ND 4.0).
Anyone may download, reuse, copy, reprint, or distribute the article without modifications or adaptations for non-profit purposes if they cite the original authors and source properly.
https://creativecommons.org/licenses/by-nc-nd/4.0/
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-03-08
タイトル
タイトル Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis.
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 anti-lactoferrin antibody
キーワード
言語 en
主題Scheme Other
主題 autoimmune disease
キーワード
言語 en
主題Scheme Other
主題 endometriosis
キーワード
言語 en
主題Scheme Other
主題 lactoferrin
キーワード
言語 en
主題Scheme Other
主題 neutrophil
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 MORI-YAMANAKA, Kaya

× MORI-YAMANAKA, Kaya

WEKO 9274

MORI-YAMANAKA, Kaya

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KIMURA, Fuminori

× KIMURA, Fuminori

WEKO 802
e-Rad 90322148
ORCID 0000-0002-9840-4227

KIMURA, Fuminori

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NAKAMURA, Akiko

× NAKAMURA, Akiko

WEKO 7754
e-Rad 70839430

NAKAMURA, Akiko

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HANADA, Tetsuro

× HANADA, Tetsuro

WEKO 7548
ORCID 0000-0001-8183-9702

HANADA, Tetsuro

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KITAZAWA, Jun

× KITAZAWA, Jun

WEKO 7753
e-Rad 30823900

KITAZAWA, Jun

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MORIMUNE, Aina

× MORIMUNE, Aina

WEKO 7755
e-Rad 60757219

MORIMUNE, Aina

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TSUJI, Shunichiro

× TSUJI, Shunichiro

WEKO 798
e-Rad 30601546
ORCID 0000-0003-3945-6817

TSUJI, Shunichiro

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MURAKAMI, Takashi

× MURAKAMI, Takashi

WEKO 564
e-Rad 20240666
ORCID 0000-0002-0250-0856

MURAKAMI, Takashi

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著者別名 森, 加也

× 森, 加也

WEKO 9274

森, 加也

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木村, 文則

× 木村, 文則

WEKO 802
e-Rad 90322148
ORCID 0000-0002-9840-4227

木村, 文則

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中村, 暁子

× 中村, 暁子

WEKO 7754
e-Rad 70839430

中村, 暁子

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花田, 哲郎

× 花田, 哲郎

WEKO 7548
ORCID 0000-0001-8183-9702

花田, 哲郎

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北澤, 純

× 北澤, 純

WEKO 7753
e-Rad 30823900

北澤, 純

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森宗, 愛菜

× 森宗, 愛菜

WEKO 7755
e-Rad 60757219

森宗, 愛菜

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辻, 俊一郎

× 辻, 俊一郎

WEKO 798
e-Rad 30601546
ORCID 0000-0003-3945-6817

辻, 俊一郎

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村上, 節

× 村上, 節

WEKO 564
e-Rad 20240666
ORCID 0000-0002-0250-0856

村上, 節

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抄録
内容記述タイプ Abstract
内容記述 Endometriosis is a disease that is characterized by the ectopic presence of the endometrium or its similar cells. A high prevalence of patients with autoimmune diseases has been reported among patients with endometriosis although the cause of endometriosis remained unknown. Recently, the anti-lactoferrin antibody is reported to be highly detected in autoimmune diseases. This study focused on lactoferrin and anti-lactoferrin antibodies to explore the pathology of endometriosis. Lactoferrin is a substance that regulates inflammation and is produced by neutrophils. Anti-lactoferrin antibody is a type of perinuclear antineutrophil cytoplasmic antibody. The serum lactoferrin and anti-lactoferrin antibody levels were compared among patients with or without endometriosis, revealing significantly higher levels in patients with endometriosis. Additionally, a decreased serum anti-lactoferrin antibody level was observed after surgical endometriosis resection. The receiver operating characteristic curve analysis determined the reference values for the serum lactoferrin and anti-lactoferrin antibody levels. Patients whose serum level exceeded the reference anti-lactoferrin antibody value were significantly higher in more than 40% of cases in the endometriosis group. The rate is comparable to that of autoimmune diseases. This is the first report that anti-lactoferrin antibody is frequently observed in patients with endometriosis, adding a new perspective to the understanding of the pathology of endometriosis although precisely elucidating the mechanism by which lactoferrin and anti-lactoferrin antibody appear in endometriosis in the future is necessary.
書誌情報 en : The Tohoku journal of experimental medicine

巻 259, 号 2, p. 135-142, 発行日 2023-01-21
出版者
出版者 Tohoku University Medical Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 1349-3329
PMID
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 36476585
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1620/tjem.2022.j106
関連名称 10.1620/tjem.2022.j106
権利
権利情報 © 2023 Tohoku University Medical Press
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
資源タイプ
内容記述タイプ Other
内容記述 Journal Article
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