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合成ペプチドを用いたMUC-1特異的細胞傷害Tリンパ球(CTL)の誘導
http://hdl.handle.net/10422/97
http://hdl.handle.net/10422/978359d981-b60a-4ca6-bdce-f3c96bd59af4
名前 / ファイル | ライセンス | アクション |
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jsums14p019.pdf (104.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-04-12 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 合成ペプチドを用いたMUC-1特異的細胞傷害Tリンパ球(CTL)の誘導 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Oligopeptides derived from MUC-1 mucin are available for inducing tumor-specific cytotoxic T lymphocytes (CTLs) | |||||
タイトル | ||||||
言語 | ja-Kana | |||||
タイトル | ゴウセイ ペプチド ヲ モチイタ MUC-1 トクイテキ サイボウ ショウガイ T リンパキュウ CTL ノ ユウドウ | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
澤井, 聡
× 澤井, 聡× 紺谷, 桂一× 花岡, 淳× 森, 渥視 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | MUC-1 mucin has been reported to carry a strong immunogenicity and to be recognized by Tlymphocytes in MHC-unrestricted manner. Also, the antigenic epitopes of this molecule are known to be locatedwithin the tandem repeat domain of MUC-1 core protein. In this study, we analyzed the ability of 30-amino acid oligopeptides (MUC-1 peptide) derived from the MUC-1 core to elicit tumor-specific CTLs in peripheralblood mononuclear cells (PBMCs) from patients with lung cancer. To determine whether the MUC-1 peptide was presented by antigen presenting cells, peptides bound on the dendritic cells (DCs) pulsedwith the MUC-1 peptide were eluted by acid-treatment and studied for reactivity to anti-MUC-1 antibodyusing spot test. Although the eluates from the DCs pulsed with the MUC-1 peptide showed the reactivity tothe antibody, no reactivity was seen in those from the DCs pulsed with non-related peptides. The inducedCTLs using the MUC-1 peptide exhibited a strong cytotoxic activity against MUC-1-expressing target cellsin the 51Cr-release assay. A strong cytotoxic activity of the CTLs was observed against the MUC-1-transduced cell line, whereas there was a weak activity against the MUC-1 deficient parent cell line. Usingsynthetic peptides is thought to be useful to induce MUC-1 specific CTLs for the purpose of immunotherapeutictreatment of cancer. | |||||
言語 | en | |||||
書誌情報 |
ja : 滋賀医科大学雑誌 巻 14, p. 19-27, 発行日 1999-02 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 滋賀医科大学雑誌刊行会 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044327 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |