{"created":"2023-06-19T10:40:34.015730+00:00","id":64,"links":{},"metadata":{"_buckets":{"deposit":"76e02359-cb28-40b2-8243-1bb421c32b4f"},"_deposit":{"created_by":3,"id":"64","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"64"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00000064","sets":["6:7:162"]},"author_link":["111","172","173","41"],"control_number":"64","item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"27","bibliographicPageStart":"19","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"滋賀医科大学雑誌","bibliographic_titleLang":"ja"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"MUC-1 mucin has been reported to carry a strong immunogenicity and to be recognized by Tlymphocytes in MHC-unrestricted manner. Also, the antigenic epitopes of this molecule are known to be locatedwithin the tandem repeat domain of MUC-1 core protein. In this study, we analyzed the ability of 30-amino acid oligopeptides (MUC-1 peptide) derived from the MUC-1 core to elicit tumor-specific CTLs in peripheralblood mononuclear cells (PBMCs) from patients with lung cancer. To determine whether the MUC-1 peptide was presented by antigen presenting cells, peptides bound on the dendritic cells (DCs) pulsedwith the MUC-1 peptide were eluted by acid-treatment and studied for reactivity to anti-MUC-1 antibodyusing spot test. Although the eluates from the DCs pulsed with the MUC-1 peptide showed the reactivity tothe antibody, no reactivity was seen in those from the DCs pulsed with non-related peptides. The inducedCTLs using the MUC-1 peptide exhibited a strong cytotoxic activity against MUC-1-expressing target cellsin the 51Cr-release assay. A strong cytotoxic activity of the CTLs was observed against the MUC-1-transduced cell line, whereas there was a weak activity against the MUC-1 deficient parent cell line. Usingsynthetic peptides is thought to be useful to induce MUC-1 specific CTLs for the purpose of immunotherapeutictreatment of cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"滋賀医科大学雑誌刊行会","subitem_publisher_language":"ja"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044327","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"澤井, 聡","creatorNameLang":"ja"},{"creatorName":"SAWAI, Satoru","creatorNameLang":"en"},{"creatorName":"サワイ, サトル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KONTANI, Keiichi","creatorNameLang":"en"},{"creatorName":"紺谷, 桂一","creatorNameLang":"ja"},{"creatorName":"コンタニ, ケイイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"花岡, 淳","creatorNameLang":"ja"},{"creatorName":"HANAOKA, Jun","creatorNameLang":"en"},{"creatorName":"ハナオカ, ジュン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"森, 渥視","creatorNameLang":"ja"},{"creatorName":"MORI, Atsumi","creatorNameLang":"en"},{"creatorName":"モリ, アツミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"jsums14p019.pdf","filesize":[{"value":"104.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jsums14p019.pdf","url":"https://shiga-med.repo.nii.ac.jp/record/64/files/jsums14p019.pdf"},"version_id":"77c701da-81a2-4d27-a7ff-dd6880f8d3d5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"合成ペプチドを用いたMUC-1特異的細胞傷害Tリンパ球(CTL)の誘導","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"合成ペプチドを用いたMUC-1特異的細胞傷害Tリンパ球(CTL)の誘導","subitem_title_language":"ja"},{"subitem_title":"Oligopeptides derived from MUC-1 mucin are available for inducing tumor-specific cytotoxic T lymphocytes (CTLs)","subitem_title_language":"en"},{"subitem_title":"ゴウセイ ペプチド ヲ モチイタ MUC-1 トクイテキ サイボウ ショウガイ T リンパキュウ CTL ノ ユウドウ","subitem_title_language":"ja-Kana"}]},"item_type_id":"3","owner":"3","path":["162"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-04-12"},"publish_date":"2016-04-12","publish_status":"0","recid":"64","relation_version_is_last":true,"title":["合成ペプチドを用いたMUC-1特異的細胞傷害Tリンパ球(CTL)の誘導"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-01-24T07:07:41.377655+00:00"}