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However, few studies have analyzed bacterial microbiota in Japanese patients with SIBO. ", "subitem_description_type": "Abstract"}, {"subitem_description": "Methods:\nTwenty-four patients with any abdominal symptoms and suspected SIBO were enrolled. Quantitative culture of duodenal aspirates and a glucose hydrogen breath test were performed on the same day. SIBO was diagnosed based on a bacterial count ≥ 103 CFU/mL or a rise in the hydrogen breath level of ≥ 20 ppm. The composition of the duodenal microbiota was analyzed by 16S rRNA gene sequencing. ", "subitem_description_type": "Abstract"}, {"subitem_description": "Results:\nSmall intestinal bacterial overgrowth was diagnosed in 17 of the 24 patients (71%). The positive rates for the hydrogen breath test and quantitative culture of duodenal aspirates were 50% and 62%, respectively. Patients with SIBO showed significantly reduced α-diversity compared with non-SIBO patients, and analysis of β-diversity revealed significantly different distributions between SIBO and non-SIBO patients. In addition, the intestinal microbiome in SIBO patients was characterized by increased relative abundance of Streptococcus and decreased relative abundance of Bacteroides compared with non-SIBO patients. ", "subitem_description_type": "Abstract"}, {"subitem_description": "Conclusions:\nDuodenal dysbiosis was identified in patients with SIBO and may play a role in the pathophysiology of SIBO. 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