@article{oai:shiga-med.repo.nii.ac.jp:00004389,
 author = {馬場, 重樹 and 今井, 隆行 and 佐々木, 雅也 and 大野, 将司 and 吉田, 晋也 and 西田, 淳史 and 高橋, 憲一郎 and 稲富, 理 and 安藤, 朗 and BAMBA, Shigeki and IMAI, Takayuki and SASAKI, Masaya and OHNO, Masashi and YOSHIDA, Shinya and NISHIDA, Atsushi and TAKAHASHI, Kenichiro and INATOMI, Osamu and ANDOH, Akira},
 journal = {Journal of gastroenterology and hepatology},
 month = {Sep},
 note = {application/pdf, Background and aim:
Small intestinal bacterial overgrowth (SIBO) is diagnosed by using quantitative culture of duodenal aspirates and/or a hydrogen breath test. However, few studies have analyzed bacterial microbiota in Japanese patients with SIBO., Methods:
Twenty-four patients with any abdominal symptoms and suspected SIBO were enrolled. Quantitative culture of duodenal aspirates and a glucose hydrogen breath test were performed on the same day. SIBO was diagnosed based on a bacterial count ≥ 103 CFU/mL or a rise in the hydrogen breath level of ≥ 20 ppm. The composition of the duodenal microbiota was analyzed by 16S rRNA gene sequencing., Results:
Small intestinal bacterial overgrowth was diagnosed in 17 of the 24 patients (71%). The positive rates for the hydrogen breath test and quantitative culture of duodenal aspirates were 50% and 62%, respectively. Patients with SIBO showed significantly reduced α-diversity compared with non-SIBO patients, and analysis of β-diversity revealed significantly different distributions between SIBO and non-SIBO patients. In addition, the intestinal microbiome in SIBO patients was characterized by increased relative abundance of Streptococcus and decreased relative abundance of Bacteroides compared with non-SIBO patients., Conclusions:
Duodenal dysbiosis was identified in patients with SIBO and may play a role in the pathophysiology of SIBO., Journal Article},
 title = {Altered gut microbiota in patients with small intestinal bacterial overgrowth.},
 year = {2022}
}