{"_buckets": {"deposit": "4332b4b5-cc5b-4d11-ba07-1b9bd018b928"}, "_deposit": {"created_by": 11, "id": "4385", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "4385"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00004385", "sets": ["228"]}, "author_link": ["644", "7639"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-11-14", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}, {"bibliographic_title": "Journal of Gastroenterology", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "安藤, 朗"}], "nameIdentifiers": [{"nameIdentifier": "644", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252395"}, {"nameIdentifier": "0000-0001-8533-2669", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8533-2669"}]}, {"creatorNames": [{"creatorName": "西田, 淳史"}], "nameIdentifiers": [{"nameIdentifier": "7639", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90719915", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90719915"}, {"nameIdentifier": "0000-0002-1288-3272", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-1288-3272"}]}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Interleukin-33 (IL-33), IL-36, and IL-38 are members of the IL-1 cytokine family. The expression of each cytokine has been reported to be increased in the inflamed mucosa of patients with inflammatory bowel disease (IBD). IL-33 and IL-36 have been studied for pro- and anti-inflammatory functions, and IL-38 has been characterized as an anti-inflammatory cytokine by antagonizing the IL-36 receptor (IL-36R). IL-33 is a nuclear cytokine constitutively expressed by certain cell types such as epithelial, endothelial, and fibroblast-like cells and released on necrotic cell death. IL-33 mainly induces type 2 immune response through its receptor suppression tumorigenicity 2 (ST2) from Th2 cells and type 2 innate lymphoid cells (ILC2s), but also by stimulating Th1 cells, regulatory T cells, and CD8+ T cells. IL-36 cytokines consist of three agonists: IL-36α, IL-36β, and IL-36γ, and two receptor antagonists: IL-36R antagonist (IL-36Ra) and IL-38. All IL-36 cytokines bind to the IL-36R complex and exert various functions through NF-κB and mitogen-activated protein kinase (MAPK) pathways in inflammatory settings. IL-33 and IL-36 also play a crucial role in intestinal fibrosis characteristic manifestation of CD. In this review, we focused on the current understanding of the pro- and anti-inflammatory roles of IL-33, IL-36, and IL38 in experimental colitis and IBD patients. ", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Nature"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "36376594", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00535-022-01936-x"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00535-022-01936-x", "subitem_relation_type_select": "DOI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2022. Japanese Society of Gastroenterology."}]}, "item_4_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0944-1174", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ANDOH, Akira"}], "nameIdentifiers": [{"nameIdentifier": "644", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252395"}, {"nameIdentifier": "0000-0001-8533-2669", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8533-2669"}]}, {"creatorNames": [{"creatorName": "NISHIDA, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "7639", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90719915", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90719915"}, {"nameIdentifier": "0000-0002-1288-3272", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-1288-3272"}]}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Alarmin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fibrosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-1RAcP", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ST2", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cytokines", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease"}]}, "item_type_id": "4", "owner": "11", "path": ["228"], "permalink_uri": "http://hdl.handle.net/10422/00013464", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-12-07"}, "publish_date": "2022-12-07", "publish_status": "0", "recid": "4385", "relation": {}, "relation_version_is_last": true, "title": ["Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease"], "weko_shared_id": -1}