{"created":"2023-06-19T10:44:01.071760+00:00","id":4385,"links":{},"metadata":{"_buckets":{"deposit":"4332b4b5-cc5b-4d11-ba07-1b9bd018b928"},"_deposit":{"created_by":11,"id":"4385","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4385"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004385","sets":["30:227:228"]},"author_link":["644","7639"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-11-14","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"Journal of Gastroenterology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安藤, 朗"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"西田, 淳史"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interleukin-33 (IL-33), IL-36, and IL-38 are members of the IL-1 cytokine family. The expression of each cytokine has been reported to be increased in the inflamed mucosa of patients with inflammatory bowel disease (IBD). IL-33 and IL-36 have been studied for pro- and anti-inflammatory functions, and IL-38 has been characterized as an anti-inflammatory cytokine by antagonizing the IL-36 receptor (IL-36R). IL-33 is a nuclear cytokine constitutively expressed by certain cell types such as epithelial, endothelial, and fibroblast-like cells and released on necrotic cell death. IL-33 mainly induces type 2 immune response through its receptor suppression tumorigenicity 2 (ST2) from Th2 cells and type 2 innate lymphoid cells (ILC2s), but also by stimulating Th1 cells, regulatory T cells, and CD8+ T cells. IL-36 cytokines consist of three agonists: IL-36α, IL-36β, and IL-36γ, and two receptor antagonists: IL-36R antagonist (IL-36Ra) and IL-38. All IL-36 cytokines bind to the IL-36R complex and exert various functions through NF-κB and mitogen-activated protein kinase (MAPK) pathways in inflammatory settings. IL-33 and IL-36 also play a crucial role in intestinal fibrosis characteristic manifestation of CD. In this review, we focused on the current understanding of the pro- and anti-inflammatory roles of IL-33, IL-36, and IL38 in experimental colitis and IBD patients. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"36376594","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1007/s00535-022-01936-x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00535-022-01936-x","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022. Japanese Society of Gastroenterology."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0944-1174","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ANDOH, Akira"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"NISHIDA, Atsushi"}],"nameIdentifiers":[{},{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alarmin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-1RAcP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ST2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease"}]},"item_type_id":"4","owner":"11","path":["228"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-12-07"},"publish_date":"2022-12-07","publish_status":"0","recid":"4385","relation_version_is_last":true,"title":["Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:09:30.014594+00:00"}