{"_buckets": {"deposit": "e22fca44-80ed-479d-9eaf-3490b7557653"}, "_deposit": {"created_by": 11, "id": "4384", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "4384"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00004384", "sets": ["267", "279"]}, "author_link": ["9204", "9203", "9207", "9205", "9206", "2764", "9031", "9208", "2869"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicVolumeNumber": "64", "bibliographic_titles": [{}, {"bibliographic_title": "Pediatrics international : official journal of the Japan Pediatric Society", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "太田, 宗樹"}], "nameIdentifiers": [{"nameIdentifier": "9031", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "越田, 繁樹"}], "nameIdentifiers": [{"nameIdentifier": "2764", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70372547", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70372547"}, {"nameIdentifier": "0000-0003-1776-8326", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-1776-8326"}]}, {"creatorNames": [{"creatorName": "丸尾, 良浩"}], "nameIdentifiers": [{"nameIdentifier": "2869", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80314160", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80314160"}]}]}, "item_4_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background:\nExosomes are nanosized extracellular vesicles, that play important roles in intercellular immune regulation. They have potential therapeutic utility for neonatal diseases including necrotizing enterocolitis. Breast-milk-derived exosomes have recently shown beneficial effects on intestinal damage in vitro and in vivo. However, the chronological change in breast-milk-derived exosome concentrations after delivery are unclear. ", "subitem_description_type": "Abstract"}, {"subitem_description": "Methods:\nIn this prospective study, we enrolled 17 mothers who delivered premature infants admitted to a neonatal intensive care unit in Japan. We measured the consecutive concentrations of breast-milk-derived exosomes in the mothers for 48 weeks after delivery. ", "subitem_description_type": "Abstract"}, {"subitem_description": "Results:\nThe median concentration of breast-milk-derived exosomes was 1.62 × 108 particles/ml in colostrum, showing a significant decrease after 2 weeks (P \u003c 0.01). There was no association between the exosome concentration in colostrum and maternal perinatal factors including parity, mode of delivery, maternal age, and gestational age at delivery. ", "subitem_description_type": "Abstract"}, {"subitem_description": "Conclusions:\nWe concluded that breast-milk-derived exosomes were the richest in colostrum. Our basic data regarding breast-milk-derived exosomes are expected to aid in the clinical application of exosomes for treating neonatal diseases. ", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "36370374", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/ped.15346"}], "subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/ped.15346", "subitem_relation_type_select": "DOI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2022 Japan Pediatric Society."}]}, "item_4_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1442-200X", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "OHTA, Motoki"}], "nameIdentifiers": [{"nameIdentifier": "9031", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOSHIDA, Shigeki"}], "nameIdentifiers": [{"nameIdentifier": "2764", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70372547", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70372547"}, {"nameIdentifier": "0000-0003-1776-8326", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-1776-8326"}]}, {"creatorNames": [{"creatorName": "JIMBO, Itsuki"}], "nameIdentifiers": [{"nameIdentifier": "9203", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ODA, Machi"}], "nameIdentifiers": [{"nameIdentifier": "9204", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "INOUE, Ryo"}], "nameIdentifiers": [{"nameIdentifier": "9205", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70443926", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70443926"}]}, {"creatorNames": [{"creatorName": "TSUKAHARA, Takamitsu"}], "nameIdentifiers": [{"nameIdentifier": "9206", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90562091", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90562091"}]}, {"creatorNames": [{"creatorName": "TERAHARA, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "9207", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAKAMURA, Yoshitaka"}], "nameIdentifiers": [{"nameIdentifier": "9208", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MARUO, Yoshihiro"}], "nameIdentifiers": [{"nameIdentifier": "2869", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80314160", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80314160"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-01-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ped.15346.pdf", "filesize": [{"value": "262.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 262000.0, "url": {"label": "ped.15346", "url": "https://shiga-med.repo.nii.ac.jp/record/4384/files/ped.15346.pdf"}, "version_id": "969b7383-52e0-4f18-a421-afd0ecf69381"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-01-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "Figure1.pdf", "filesize": [{"value": "53.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 53500.0, "url": {"label": "Figure1", "url": "https://shiga-med.repo.nii.ac.jp/record/4384/files/Figure1.pdf"}, "version_id": "ae16cc07-bd40-4a61-9eeb-25641b77c64a"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-01-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "Figure2.pdf", "filesize": [{"value": "41.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 41800.0, "url": {"label": "Figure2", "url": "https://shiga-med.repo.nii.ac.jp/record/4384/files/Figure2.pdf"}, "version_id": "5ada1c49-4342-4047-9c1c-918882d01104"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "breast milk", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "colostrum", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "exosome", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neonate", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "preterm", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Highest concentration of breast-milk-derived exosomes in colostrum.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Highest concentration of breast-milk-derived exosomes in colostrum."}]}, "item_type_id": "4", "owner": "11", "path": ["267", "279"], "permalink_uri": "http://hdl.handle.net/10422/00013463", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-12-07"}, "publish_date": "2022-12-07", "publish_status": "0", "recid": "4384", "relation": {}, "relation_version_is_last": true, "title": ["Highest concentration of breast-milk-derived exosomes in colostrum."], "weko_shared_id": -1}