{"created":"2023-06-19T10:44:01.008284+00:00","id":4384,"links":{},"metadata":{"_buckets":{"deposit":"e22fca44-80ed-479d-9eaf-3490b7557653"},"_deposit":{"created_by":11,"id":"4384","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4384"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004384","sets":["30:68:267","77:278:279"]},"author_link":["9204","9203","9207","9205","9206","2764","9031","9208","2869"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"64","bibliographic_titles":[{},{"bibliographic_title":"Pediatrics international : official journal of the Japan Pediatric Society","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"太田, 宗樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"越田, 繁樹"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"丸尾, 良浩"}],"nameIdentifiers":[{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:\nExosomes are nanosized extracellular vesicles, that play important roles in intercellular immune regulation. They have potential therapeutic utility for neonatal diseases including necrotizing enterocolitis. Breast-milk-derived exosomes have recently shown beneficial effects on intestinal damage in vitro and in vivo. However, the chronological change in breast-milk-derived exosome concentrations after delivery are unclear. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nIn this prospective study, we enrolled 17 mothers who delivered premature infants admitted to a neonatal intensive care unit in Japan. We measured the consecutive concentrations of breast-milk-derived exosomes in the mothers for 48 weeks after delivery. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nThe median concentration of breast-milk-derived exosomes was 1.62 × 108 particles/ml in colostrum, showing a significant decrease after 2 weeks (P < 0.01). There was no association between the exosome concentration in colostrum and maternal perinatal factors including parity, mode of delivery, maternal age, and gestational age at delivery. ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions:\nWe concluded that breast-milk-derived exosomes were the richest in colostrum. Our basic data regarding breast-milk-derived exosomes are expected to aid in the clinical application of exosomes for treating neonatal diseases. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"36370374","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1111/ped.15346"}],"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/ped.15346","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 Japan Pediatric Society."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1442-200X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OHTA, Motoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOSHIDA, Shigeki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"JIMBO, Itsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ODA, Machi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INOUE, Ryo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TSUKAHARA, Takamitsu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TERAHARA, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Yoshitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MARUO, Yoshihiro"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-01"}],"displaytype":"detail","filename":"ped.15346.pdf","filesize":[{"value":"262.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ped.15346","url":"https://shiga-med.repo.nii.ac.jp/record/4384/files/ped.15346.pdf"},"version_id":"969b7383-52e0-4f18-a421-afd0ecf69381"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-01"}],"displaytype":"detail","filename":"Figure1.pdf","filesize":[{"value":"53.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Figure1","url":"https://shiga-med.repo.nii.ac.jp/record/4384/files/Figure1.pdf"},"version_id":"ae16cc07-bd40-4a61-9eeb-25641b77c64a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-01"}],"displaytype":"detail","filename":"Figure2.pdf","filesize":[{"value":"41.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Figure2","url":"https://shiga-med.repo.nii.ac.jp/record/4384/files/Figure2.pdf"},"version_id":"5ada1c49-4342-4047-9c1c-918882d01104"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"breast milk","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colostrum","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"exosome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neonate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"preterm","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Highest concentration of breast-milk-derived exosomes in colostrum.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Highest concentration of breast-milk-derived exosomes in colostrum."}]},"item_type_id":"4","owner":"11","path":["267","279"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-12-07"},"publish_date":"2022-12-07","publish_status":"0","recid":"4384","relation_version_is_last":true,"title":["Highest concentration of breast-milk-derived exosomes in colostrum."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:09:34.074197+00:00"}