{"_buckets": {"deposit": "70439ae6-ae8f-41d5-b00a-b2f3c9d8836b"}, "_deposit": {"created_by": 11, "id": "3458", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "3458"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00003458", "sets": ["205"]}, "author_link": ["6759", "812", "844", "6933", "6959", "7505", "1985", "268", "696", "6759", "812", "844", "6933", "7505", "1985", "268", "696"], "control_number": "3458", "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "13", "bibliographicPageEnd": "4804", "bibliographicPageStart": "4791", "bibliographicVolumeNumber": "26", "bibliographic_titles": [{"bibliographic_title": "Annals of surgical oncology", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "前平, 博充", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "6759", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "0000-0003-3064-5216", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-3064-5216"}]}, {"creatorNames": [{"creatorName": "三宅, 亨", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "812", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70581924", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70581924"}]}, {"creatorNames": [{"creatorName": "飯田, 洋也", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "844", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30733901", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30733901"}, {"nameIdentifier": "0000-0001-6245-4583", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-6245-4583"}]}, {"creatorNames": [{"creatorName": "徳田, 彩", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "6933", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80814392", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80814392"}]}, {"creatorNames": [{"creatorName": "森, 治樹", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "安川, 大貴", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "7505", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80765074", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80765074"}]}, {"creatorNames": [{"creatorName": "向所, 賢一", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "1985", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50343223", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50343223"}, {"nameIdentifier": "0000-0002-0488-0100", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-0488-0100"}]}, {"creatorNames": [{"creatorName": "清水, 智治", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "268", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70402708", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70402708"}, {"nameIdentifier": "0000-0002-2858-0786", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-2858-0786"}]}, {"creatorNames": [{"creatorName": "谷, 眞至", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "696", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60236677", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60236677"}, {"nameIdentifier": "0000-0003-1270-6003", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-1270-6003"}]}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "BACKGROUND:The tumor microenvironment, including cancer-associated fibroblasts (CAFs), plays various clinical roles in cancer growth. CAFs are a heterogeneous population and express a variety of mesenchymal markers. However, the clinical roles for CAFs expressing different markers in pancreatic ductal adenocarcinoma (PDAC) remain unknown.\n\nMETHODS:We reviewed 67 resected PDAC patients who had not received preoperative therapy. Each primary tumor was analyzed for vimentin and α-smooth muscle actin (α-SMA) expression by immunohistochemical and dual immunofluorescence staining.\n\nRESULTS:There was no correlation between the percentage of cells expressing vimentin and α-SMA in the tumor stroma (Pearson\u0027s correlation coefficient: r = 0.171). Higher vimentin expression (p = 0.018) was associated with significantly shorter overall survival in PDAC patients. Using dual immunofluorescence staining, vimentin-positive CAFs were divided into two subpopulations: co-expression of α-SMA, and no co-expression of α-SMA. In PDAC, the level of co-expression had no effect on survival using univariate analysis (median survival time, 33.3 months for low co-expression vs. 18.2 months for high co-expression; log-rank, p = 0.143). However, multivariate analysis clarified that CAFs expressing vimentin alone was an independent predictor of poor survival (p = 0.014; hazard ratio, 2.305; 95% confidence interval, 1.181-4.497).\n\nCONCLUSIONS:Vimentin-positive CAFs without co-expression of α-SMA were associated with poor survival in PDAC, and CAFs possessed molecular and functional heterogeneity in this disease.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer International Publishing", "subitem_publisher_language": "en"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "31583548", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1245/s10434-019-07891-x", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_48": {"attribute_name": "関係URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "博士論文要旨"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://hdl.handle.net/10422/00012688", "subitem_relation_type_select": "HDL"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© Society of Surgical Oncology 2019", "subitem_rights_language": "en"}]}, "item_4_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1534-4681", "subitem_source_identifier_type": "EISSN"}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": 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