{"created":"2023-06-19T10:43:15.500553+00:00","id":3458,"links":{},"metadata":{"_buckets":{"deposit":"70439ae6-ae8f-41d5-b00a-b2f3c9d8836b"},"_deposit":{"created_by":11,"id":"3458","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3458"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003458","sets":["30:204:205"]},"author_link":["6759","812","844","6933","6959","7505","1985","268","696","6759","812","844","6933","7505","1985","268","696"],"control_number":"3458","item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"13","bibliographicPageEnd":"4804","bibliographicPageStart":"4791","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Annals of surgical oncology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前平, 博充","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"三宅, 亨","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"飯田, 洋也","creatorNameLang":"ja"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"徳田, 彩","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"森, 治樹","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"安川, 大貴","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"向所, 賢一","creatorNameLang":"ja"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"清水, 智治","creatorNameLang":"ja"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"谷, 眞至","creatorNameLang":"ja"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND:The tumor microenvironment, including cancer-associated fibroblasts (CAFs), plays various clinical roles in cancer growth. CAFs are a heterogeneous population and express a variety of mesenchymal markers. However, the clinical roles for CAFs expressing different markers in pancreatic ductal adenocarcinoma (PDAC) remain unknown.\n\nMETHODS:We reviewed 67 resected PDAC patients who had not received preoperative therapy. Each primary tumor was analyzed for vimentin and α-smooth muscle actin (α-SMA) expression by immunohistochemical and dual immunofluorescence staining.\n\nRESULTS:There was no correlation between the percentage of cells expressing vimentin and α-SMA in the tumor stroma (Pearson's correlation coefficient: r = 0.171). Higher vimentin expression (p = 0.018) was associated with significantly shorter overall survival in PDAC patients. Using dual immunofluorescence staining, vimentin-positive CAFs were divided into two subpopulations: co-expression of α-SMA, and no co-expression of α-SMA. In PDAC, the level of co-expression had no effect on survival using univariate analysis (median survival time, 33.3 months for low co-expression vs. 18.2 months for high co-expression; log-rank, p = 0.143). However, multivariate analysis clarified that CAFs expressing vimentin alone was an independent predictor of poor survival (p = 0.014; hazard ratio, 2.305; 95% confidence interval, 1.181-4.497).\n\nCONCLUSIONS:Vimentin-positive CAFs without co-expression of α-SMA were associated with poor survival in PDAC, and CAFs possessed molecular and functional heterogeneity in this disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer International Publishing","subitem_publisher_language":"en"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31583548","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1245/s10434-019-07891-x","subitem_relation_type_select":"DOI"}}]},"item_4_relation_48":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"博士論文要旨"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10422/00012688","subitem_relation_type_select":"HDL"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Society of Surgical Oncology 2019","subitem_rights_language":"en"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1534-4681","subitem_source_identifier_type":"EISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MAEHIRA, Hiromitsu","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MIYAKE, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"IIDA, Hiroya","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"TOKUDA, Aya","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MORI, Haruki","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YASUKAWA, Daiki","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MUKAISHO, Ken-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Tomoharu","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"TANI, Masaji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-03"}],"displaytype":"detail","filename":"s10434-019-07891-x.pdf","filesize":[{"value":"242.4 kB"}],"format":"application/pdf","license_note":"© Society of Surgical Oncology 2019","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s10434-019-07891-x","url":"https://shiga-med.repo.nii.ac.jp/record/3458/files/s10434-019-07891-x.pdf"},"version_id":"d6e74ec4-ec85-4e42-8a3f-cce1003a2e4f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-03"}],"displaytype":"detail","filename":"Supplementary material.zip","filesize":[{"value":"1.1 MB"}],"format":"application/x-zip-compressed","license_note":"© Society of Surgical Oncology 2019","licensetype":"license_note","mimetype":"application/zip","url":{"label":"Supplementary material","url":"https://shiga-med.repo.nii.ac.jp/record/3458/files/Supplementary material.zip"},"version_id":"6783c86d-d84e-4212-933d-6ece88672de7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Vimentin Expression in Tumor Microenvironment Predicts Survival in Pancreatic Ductal Adenocarcinoma: Heterogeneity in Fibroblast Population.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Vimentin Expression in Tumor Microenvironment Predicts Survival in Pancreatic Ductal Adenocarcinoma: Heterogeneity in Fibroblast Population.","subitem_title_language":"en"}]},"item_type_id":"4","owner":"11","path":["205"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-11-26"},"publish_date":"2019-11-26","publish_status":"0","recid":"3458","relation_version_is_last":true,"title":["Vimentin Expression in Tumor Microenvironment Predicts Survival in Pancreatic Ductal Adenocarcinoma: Heterogeneity in Fibroblast Population."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-10-18T02:04:42.831446+00:00"}