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  1. 学位論文
  2. 博士論文（医学）

Progression risk assessments of individual non-invasive gastric neoplasms by genomic copy-number profile and mucin phenotype.

http://hdl.handle.net/10422/00012495
http://hdl.handle.net/10422/00012495
c14a9587-6557-4aa9-b0b1-2c514ec5996d
名前 / ファイル ライセンス アクション
s12920-015-0080-6.pdf s12920-015-0080-6 (2.0 MB)
12920_2015_80_MOESM1_ESM.pdf Additional files 1 (139.6 kB)
12920_2015_80_MOESM2_ESM.pdf Additional files 2 (72.0 kB)
12920_2015_80_MOESM3a_ESM.pdf Additional files 3a (2.2 MB)
12920_2015_80_MOESM3b_ESM.png Additional files 3b (1.4 MB)
12920_2015_80_MOESM4_ESM.pdf Additional files 4 (2.2 MB)
12920_2015_80_MOESM5_ESM.pdf Additional files 5 (90.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-03-04
タイトル
タイトル Progression risk assessments of individual non-invasive gastric neoplasms by genomic copy-number profile and mucin phenotype.
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 VO, Thi Ngoc Diem

× VO, Thi Ngoc Diem

en VO, Thi Ngoc Diem
Search repository
抄録
内容記述タイプ Abstract
内容記述 Background:
Early detection and treatment of non-invasive neoplasms can effectively reduce the incidence of advanced gastric carcinoma (GC), but only when the lineage is continuous between non-invasive and advanced tumours. Although a fraction of non-invasive neoplasms progress to invasive GC, it is difficult to identify individual progression-prone non-invasive neoplasms. To classify non-invasive gland-forming gastric neoplasms into clusters of different levels of progression risk, we applied mucin phenotyping and genomic DNA microarray analyses to intramucosal gland-forming gastric neoplasms.
言語 en
抄録
内容記述タイプ Abstract
内容記述 Methods:
Formalin-fixed, paraffin-embedded tissues from 19 non-invasive and 24 invasive gland-forming neoplasms were obtained via endoscopic submucosal dissection or surgical excision. According to the Vienna classification, intramucosal neoplasms were classified as low-grade or high-grade non-invasive neoplasms (LGNs [category 3] and HGNs [category 4], respectively) or invasive carcinomas (intramucosal GCs and mucosal parts of submucosal or deeper GCs [category 5]). Neoplastic lesions were characterized by mucin phenotypes determined using monoclonal antibodies against MUC2, MUC5AC, MUC6, and CD10. Genomic DNA samples from mucosal neoplasms were subjected to array-based comparative genomic hybridization and subsequent unsupervised, hierarchical clustering with selected large-sized genes.
言語 en
抄録
内容記述タイプ Abstract
内容記述 Results:
There was no significant difference in mucin phenotype between HGNs/LGNs and invasive carcinomas. The clustering classified samples into stable, unstable, and intermediate. The histological tumour grade or mucin phenotype of non-invasive neoplasms did not correlate with the clustering results. Each cluster may represent an independent lineage of different outcome because the size distribution of non-invasive tumours among the 3 clusters almost overlapped. In contrast, the unstable cluster alone included invasive carcinomas.
言語 en
抄録
内容記述タイプ Abstract
内容記述 Conclusions:
These findings suggest that the outcome of individual tumours is not stochastically determined but can be predicted from the genomic copy-number profile even at the non-invasive stage. Non-invasive neoplasms of the unstable clusters, which accounted for 21% of non-invasive neoplasms, may progress to invasive carcinomas, whereas those of stable cluster may not.
言語 en
学位名
言語 ja
学位名 博士（医学）
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 14202
言語 ja
学位授与機関名 滋賀医科大学
学位授与年度
内容記述タイプ Other
内容記述 平成27年度
言語 ja
学位授与年月日
学位授与年月日 2015-09-09
学位授与番号
学位授与番号 甲第733号
書誌情報 en : BMC Medical Genomics

巻 8, 号 6, 発行日 2015-02-18
出版者
出版者 BioMed Central Ltd.
言語 en
著者版フラグ
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ISSN
収録物識別子タイプ EISSN
収録物識別子 1755-8794
PMID
識別子タイプ PMID
関連識別子 25881098
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12920-015-0080-6
関連名称 10.1186/s12920-015-0080-6.
資源タイプ
内容記述タイプ Other
内容記述 Thesis or Dissertation
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