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Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis
http://hdl.handle.net/10422/0002000041
http://hdl.handle.net/10422/00020000411c4aa969-e1ef-4f52-9fe2-6abc9bb9899b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
rmb2.12540.pdf (5.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-11-22 | |||||
| タイトル | ||||||
| タイトル | Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | CA-125 antigen | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | endometriosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | intraperitoneal injections | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Macaca fascicularis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | mesenchymal stem cells | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
TSUJI, Ichiro
× TSUJI, Ichiro× MUKAI, Takeo× TSUCHIYA, Hideaki× IWATANI, Chizuru× NAKAMURA, Akiko× NAGAMURA-INOUE, Tokiko× MURAKAMI, Takashi |
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| 著者別名 |
辻, 俊一郎
× 辻, 俊一郎× 土屋, 英明× 岩谷, 千鶴× 中村, 暁子× 村上, 節 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: This study aimed to explore whether umbilical cord-derived mesenchymal stem cells (UC-MSCs) could be used as a therapeutic resource for endometriosis. Methods: Of seven cynomolgus monkeys with endometriosis, five were administered UC-MSCs (intervention group) and two were administered saline (control group). First, intravenous US-MSC treatment was administered for three months. Second, weekly intravenous US-MSC administration combined with monthly intraperitoneal US-MSC administration was conducted for 3 months. Finally, weekly intraperitoneal US-MSC administration was conducted for 3 months. The dose of UC-MSCs was set to 2 × 106 cells/kg for all administration routes. Laparoscopic findings and serum cancer antigen 125 (CA125) levels were also evaluated. The Revised American Society for Reproductive Medicine classification was used for laparoscopic evaluation. Results: Laparoscopic findings showed exacerbation of endometriosis after intraperitoneal UC-MSC administration, although no changes were observed in the control group. Intravenous UC-MSC administration decreased the level of CA125 in all monkeys; however, the difference was not significant. Intraperitoneal UC-MSC administration significantly exacerbated endometriosis compared with intravenous administration (p = 0.02). Conclusions: This study revealed that intraperitoneal UC-MSC administration exacerbates endometriosis in a nonhuman primate model of the disease. |
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| 言語 | en | |||||
| 書誌情報 |
en : Reproductive medicine and biology 巻 22, 号 1, 発行日 2023-08-28 |
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| 出版者 | ||||||
| 出版者 | Japan Society for Reproductive Medicine | |||||
| 言語 | en | |||||
| 別言語の出版者 | ||||||
| 出版者 | 日本生殖医学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1447-0578 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 37693240 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10491929/ | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1002/rmb2.12540 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2023 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
