{"created":"2023-11-22T02:34:05.519200+00:00","id":2000041,"links":{},"metadata":{"_buckets":{"deposit":"1721f44b-7c4a-4dda-9105-bd99eb5bcd1a"},"_deposit":{"created_by":11,"id":"2000041","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000041"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:02000041","sets":["19:82:83","30:66:216"]},"author_link":["9400","7885","4000","4059","7754","564","798","4000","4059","7754","564"],"control_number":"2000041","item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-08-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Reproductive medicine and biology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻, 俊一郎","creatorNameLang":"ja"},{"creatorName":"ツジ, シュンイチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"土屋, 英明","creatorNameLang":"ja"},{"creatorName":"ツチヤ, ヒデアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"岩谷, 千鶴","creatorNameLang":"ja"},{"creatorName":"イワタニ, チヅル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中村, 暁子","creatorNameLang":"ja"},{"creatorName":"ナカムラ, アキコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"村上, 節","creatorNameLang":"ja"},{"creatorName":"ムラカミ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: \nThis study aimed to explore whether umbilical cord-derived mesenchymal stem cells (UC-MSCs) could be used as a therapeutic resource for endometriosis. \nMethods: \nOf seven cynomolgus monkeys with endometriosis, five were administered UC-MSCs (intervention group) and two were administered saline (control group). First, intravenous US-MSC treatment was administered for three months. Second, weekly intravenous US-MSC administration combined with monthly intraperitoneal US-MSC administration was conducted for 3 months. Finally, weekly intraperitoneal US-MSC administration was conducted for 3 months. The dose of UC-MSCs was set to 2 × 106 cells/kg for all administration routes. Laparoscopic findings and serum cancer antigen 125 (CA125) levels were also evaluated. The Revised American Society for Reproductive Medicine classification was used for laparoscopic evaluation. \nResults: \nLaparoscopic findings showed exacerbation of endometriosis after intraperitoneal UC-MSC administration, although no changes were observed in the control group. Intravenous UC-MSC administration decreased the level of CA125 in all monkeys; however, the difference was not significant. Intraperitoneal UC-MSC administration significantly exacerbated endometriosis compared with intravenous administration (p = 0.02). \nConclusions: \nThis study revealed that intraperitoneal UC-MSC administration exacerbates endometriosis in a nonhuman primate model of the disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Society for Reproductive Medicine","subitem_publisher_language":"en"}]},"item_4_publisher_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_publisher":"日本生殖医学会","subitem_publisher_language":"ja"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"37693240","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/rmb2.12540","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10491929/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.","subitem_rights_language":"en"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1447-0578","subitem_source_identifier_type":"EISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TSUJI, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MUKAI, Takeo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUCHIYA, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"IWATANI, Chizuru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAGAMURA-INOUE, Tokiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MURAKAMI, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-11-22"}],"displaytype":"detail","filename":"rmb2.12540.pdf","filesize":[{"value":"5.9 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"url":"https://shiga-med.repo.nii.ac.jp/record/2000041/files/rmb2.12540.pdf"},"version_id":"821c27c1-c8d1-4713-b6ba-0e04d9e48118"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CA-125 antigen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endometriosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intraperitoneal injections","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Macaca fascicularis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mesenchymal stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis","subitem_title_language":"en"}]},"item_type_id":"4","owner":"11","path":["216","83"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-22"},"publish_date":"2023-11-22","publish_status":"0","recid":"2000041","relation_version_is_last":true,"title":["Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-11-22T03:24:25.764502+00:00"}