Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2023-04-17 |
タイトル |
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タイトル |
Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study. |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
(123)I-MIBG myocardial scintigraphy |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Alpha-synuclein |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Dopamine transporter single-photon emission computed tomography |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Idiopathic rapid eye movement sleep behavior disorder |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Prodromal Parkinson's disease |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
著者 |
NISHIKAWA, Noriko
MURATA, Miho
HATANO, Taku
MUKAI, Yohei
SAITOH, Yuji
SAKAMOTO, Takashi
HANAKAWA, Takashi
KAMEI, Yuichi
TACHIMORI, Hisateru
HATANO, Kenji
MATSUDA, Hiroshi
TARUNO, Yosuke
SAWAMOTO, Nobukatsu
KAJIYAMA, Yuta
IKENAKA, Kensuke
KAWABATA, Kazuya
NAKAMURA, Tomohiko
IWAKI, Hirotaka
角谷, 寛
SUMI, Yukiyoshi
INOUE, Yuichi
HAYASHI, Toshihiro
IKEUCHI, Takeshi
SHIMO, Yasushi
MOCHIZUKI, Hideki
WATANABE, Hirohisa
HATTORI, Nobutaka
TAKAHASHI, Yuji
TAKAHASHI, Ryosuke
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著者別名 |
角谷, 寛
角, 幸頼
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Introduction: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is one of the most specific prodromal symptoms of synucleinopathies, including Parkinson's disease (PD) and multiple system atrophy. The Japan Parkinson's Progression Markers Initiative (J-PPMI) was a prospective cohort study conducted in Japanese patients with iRBD to investigate biomarkers for prodromal synucleinopathies. We carried out an initial assessment of the J-PPMI study to reveal the factors correlated with dopamine transporter single-photon emission computed tomography (DaT) and 123I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy. |
抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Methods: This cross-sectional study was conducted in 108 patients with iRBD, selected from the J-PPMI study. We divided the patients into four groups based on the MIBG and DaT results. We also recorded the patients' demographics and clinical data. Following PD probability calculation, we examined the biomarkers associated with DaT and MIBG. |
抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Results: Ninety-five of the enrolled patients (88%) met the diagnostic criteria for prodromal PD based on the probability score. Only five patients had normal MIBG and DaT. We identified 29 cases with decreased DaT and MIBG, all of whom met the above diagnostic criteria. Both DaT and MIBG were significantly correlated with the Japanese version of the Montreal Cognitive Assessment (MoCA-J) score. |
抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Conclusion:Both DaT and MIBG are important biomarkers for confirming synucleinopathies and/or staging disease progression. Although 95% of iRBD patients were consistent with the body-first subtype concept, alpha-synuclein pathologies of iRBD might have widespread systemic involvement rather than being confined to the lower brainstem, particularly in patients with reduced MoCA-J scores. |
書誌情報 |
en : Parkinsonism & related disorders
巻 103,
p. 129-135,
発行日 2022-10
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出版者 |
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出版者 |
Elsevier Ltd. |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1873-5126 |
PMID |
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関連タイプ |
isVersionOf |
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識別子タイプ |
PMID |
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関連識別子 |
36113390 |
DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.parkreldis.2022.08.011 |
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関連名称 |
10.1016/j.parkreldis.2022.08.011 |
権利 |
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権利情報 |
© 2022 Elsevier Ltd. All rights reserved. |
フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
著者版フラグ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
資源タイプ |
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内容記述タイプ |
Other |
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内容記述 |
Journal Article |