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Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis.
http://hdl.handle.net/10422/00013072
http://hdl.handle.net/10422/000130721534556c-7677-4fcf-802e-1b810d0a98ae
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
000518908 (486.5 kB)
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This article is licensed under the Creative Commons Attribution 4.0
International License (CC BY) (http://www.karger.com/Services/ OpenAccessLicense). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher. |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-15 | |||||
| タイトル | ||||||
| タイトル | Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Body composition | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Indirect calorimetry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Sarcopenia | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
KURIHARA, Mika
× KURIHARA, Mika× BAMBA, Shigeki× YASUHARA, Shoko× ITOH, Akihiko× NAGAO, Taishi× NAKANISHI, Naoko× NAKAMURA, Ryutaro× OGAWA, Nobuhiro× KITAMURA, Akihiro× YAMAKAWA, Isamu× KIM, Hyoh× SANADA, Mitsuru× URUSHITANI, Makoto× SASAKI, Masaya |
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| 著者別名 |
栗原, 美香
× 栗原, 美香× 馬場, 重樹× 安原, 祥子× 伊藤, 明彦× 長尾, 大志× 中西, 直子× 中村, 竜太郎× 小川, 暢弘× 北村, 彰浩× 山川, 勇× 金, 哲将× 真田, 充× 漆谷, 真× 佐々木, 雅也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/aims: Nutritional status is a factor affecting prognosis in patients with amyotrophic lateral sclerosis (ALS). Here, we aimed to clarify the factors associated with hypermetabolism and the prognosticators of ALS. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Methods: Forty-two inpatients (22 men, 20 women) diagnosed with ALS according to the revised El-Escorial criteria were investigated. The following data were retrospectively analyzed: anthropometric measurements, blood biochemistry, disease severity, basal energy expenditure (BEE), resting energy expenditure (REE) measured by indirect calorimetry, spirometry, and bioelectrical impedance analysis. Single and multiple regression analysis was performed to examine factors affecting REE and metabolic changes (defined as the ratio of REE to fat-free mass [FFM]). The Kaplan-Meier method was used to examine factors associated with the occurrence of cumulative events (death or tracheostomy). |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Results: Among the 42 inpatients, REE was significantly higher than BEE, indicating hypermetabolism in ALS. Multiple regression analysis revealed that REE/FFM is strongly associated with the skeletal muscle index (-3.746 to -1.532, p < 0.0001) and percent forced vital capacity (%FVC) (-0.172 to -0.021, p = 0.013). Moreover, both the skeletal muscle index and %FVC were significant prognosticators associated with the occurrence of cumulative events. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Conclusions: Energy metabolism was elevated in ALS, and respiratory status and muscle mass were associated with the hypermetabolism and poor prognosis. Adequate nutritional support may improve outcomes in ALS by preventing deterioration of respiratory status and reduction in muscle mass. |
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| 書誌情報 |
en : Annals of nutrition & metabolism 巻 77, 号 4, p. 236-243, 発行日 2021-08-24 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1421-9697 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34515052 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1159/000518908 | |||||
| 関連名称 | 10.1159/000518908 | |||||
| 権利 | ||||||
| 権利情報 | © 2021 The Author(s). Published by S. Karger AG, Basel. | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
