{"created":"2023-06-19T10:43:41.841303+00:00","id":3974,"links":{},"metadata":{"_buckets":{"deposit":"54e05219-5c09-4a60-b416-8c8fb916efe5"},"_deposit":{"created_by":11,"id":"3974","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3974"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003974","sets":["30:198:199","30:214:215","77:242:243"]},"author_link":["2836","316","552","7986","707","3015","7948","1956","2501","643","7950","636","8493","3102","2784"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"243","bibliographicPageStart":"236","bibliographicVolumeNumber":"77","bibliographic_titles":[{},{"bibliographic_title":"Annals of nutrition & metabolism","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"栗原, 美香"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"馬場, 重樹"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"安原, 祥子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 明彦"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"長尾, 大志"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中西, 直子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中村, 竜太郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川, 暢弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北村, 彰浩"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"山川, 勇"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"金, 哲将"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"真田, 充"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"漆谷, 真"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"佐々木, 雅也"}],"nameIdentifiers":[{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/aims:\nNutritional status is a factor affecting prognosis in patients with amyotrophic lateral sclerosis (ALS). Here, we aimed to clarify the factors associated with hypermetabolism and the prognosticators of ALS. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nForty-two inpatients (22 men, 20 women) diagnosed with ALS according to the revised El-Escorial criteria were investigated. The following data were retrospectively analyzed: anthropometric measurements, blood biochemistry, disease severity, basal energy expenditure (BEE), resting energy expenditure (REE) measured by indirect calorimetry, spirometry, and bioelectrical impedance analysis. Single and multiple regression analysis was performed to examine factors affecting REE and metabolic changes (defined as the ratio of REE to fat-free mass [FFM]). The Kaplan-Meier method was used to examine factors associated with the occurrence of cumulative events (death or tracheostomy).","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nAmong the 42 inpatients, REE was significantly higher than BEE, indicating hypermetabolism in ALS. Multiple regression analysis revealed that REE/FFM is strongly associated with the skeletal muscle index (-3.746 to -1.532, p < 0.0001) and percent forced vital capacity (%FVC) (-0.172 to -0.021, p = 0.013). Moreover, both the skeletal muscle index and %FVC were significant prognosticators associated with the occurrence of cumulative events. ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions:\nEnergy metabolism was elevated in ALS, and respiratory status and muscle mass were associated with the hypermetabolism and poor prognosis. Adequate nutritional support may improve outcomes in ALS by preventing deterioration of respiratory status and reduction in muscle mass. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"34515052","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1159/000518908"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1159/000518908","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 The Author(s). Published by S. Karger AG, Basel. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1421-9697","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KURIHARA, Mika"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"BAMBA, Shigeki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"YASUHARA, Shoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ITOH, Akihiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAGAO, Taishi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKANISHI, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Ryutaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OGAWA, Nobuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KITAMURA, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YAMAKAWA, Isamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KIM, Hyoh"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SANADA, Mitsuru"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"URUSHITANI, Makoto"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SASAKI, Masaya"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-15"}],"displaytype":"detail","filename":"000518908.pdf","filesize":[{"value":"486.5 kB"}],"format":"application/pdf","license_note":"This article is licensed under the Creative Commons Attribution 4.0\nInternational License (CC BY) (http://www.karger.com/Services/\nOpenAccessLicense). Usage, derivative works and distribution are\npermitted provided that proper credit is given to the author and the\noriginal publisher.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000518908","url":"https://shiga-med.repo.nii.ac.jp/record/3974/files/000518908.pdf"},"version_id":"84f22988-9562-4474-9829-e4a7e2d27236"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Body composition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Indirect calorimetry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sarcopenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis."}]},"item_type_id":"4","owner":"11","path":["199","215","243"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-15"},"publish_date":"2021-09-15","publish_status":"0","recid":"3974","relation_version_is_last":true,"title":["Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:22:09.061145+00:00"}