@article{oai:shiga-med.repo.nii.ac.jp:00003974,
 author = {栗原, 美香 and 馬場, 重樹 and 安原, 祥子 and 伊藤, 明彦 and 長尾, 大志 and 中西, 直子 and 中村, 竜太郎 and 小川, 暢弘 and 北村, 彰浩 and 山川, 勇 and 金, 哲将 and 真田, 充 and 漆谷, 真 and 佐々木, 雅也 and KURIHARA, Mika and BAMBA, Shigeki and YASUHARA, Shoko and ITOH, Akihiko and NAGAO, Taishi and NAKANISHI, Naoko and NAKAMURA, Ryutaro and OGAWA, Nobuhiro and KITAMURA, Akihiro and YAMAKAWA, Isamu and KIM, Hyoh and SANADA, Mitsuru and URUSHITANI, Makoto and SASAKI, Masaya},
 issue = {4},
 journal = {Annals of nutrition & metabolism},
 month = {Aug},
 note = {pdf, Background/aims:
Nutritional status is a factor affecting prognosis in patients with amyotrophic lateral sclerosis (ALS). Here, we aimed to clarify the factors associated with hypermetabolism and the prognosticators of ALS., Methods:
Forty-two inpatients (22 men, 20 women) diagnosed with ALS according to the revised El-Escorial criteria were investigated. The following data were retrospectively analyzed: anthropometric measurements, blood biochemistry, disease severity, basal energy expenditure (BEE), resting energy expenditure (REE) measured by indirect calorimetry, spirometry, and bioelectrical impedance analysis. Single and multiple regression analysis was performed to examine factors affecting REE and metabolic changes (defined as the ratio of REE to fat-free mass [FFM]). The Kaplan-Meier method was used to examine factors associated with the occurrence of cumulative events (death or tracheostomy)., Results:
Among the 42 inpatients, REE was significantly higher than BEE, indicating hypermetabolism in ALS. Multiple regression analysis revealed that REE/FFM is strongly associated with the skeletal muscle index (-3.746 to -1.532, p < 0.0001) and percent forced vital capacity (%FVC) (-0.172 to -0.021, p = 0.013). Moreover, both the skeletal muscle index and %FVC were significant prognosticators associated with the occurrence of cumulative events., Conclusions:
Energy metabolism was elevated in ALS, and respiratory status and muscle mass were associated with the hypermetabolism and poor prognosis. Adequate nutritional support may improve outcomes in ALS by preventing deterioration of respiratory status and reduction in muscle mass., Journal Article},
 pages = {236--243},
 title = {Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis.},
 volume = {77},
 year = {2021}
}