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A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury.
http://hdl.handle.net/10422/00012937
http://hdl.handle.net/10422/00012937d6ad7b4d-cd8d-4ceb-af28-7eae9b2e21f1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
s41598-021-84818-1 (9.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-07 | |||||
| タイトル | ||||||
| タイトル | A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Biophysics | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Biotechnology | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cell biology | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Developmental biology | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
OKANO, Junko
× OKANO, Junko× Nakae, Yuki× NAKAGAWA, Takahiko× KATAGI, Miwako× TERASHIMA, Tomoya× NAGAKUBO, Daisuke× NAKAYAMA, Takashi× YOSHIE, Osamu× SUZUKI, Yoshihisa× KOJIMA, Hideto |
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| 著者別名 |
岡野, 純子
× 岡野, 純子× 中江, 由希× 仲川, 孝彦× 樫, 美和子× 寺島, 智也× 長久保, 大輔× 鈴木, 義久× 小島, 秀人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery. | |||||
| 書誌情報 |
en : Scientific Reports 巻 11, 号 1, 発行日 2021-03-11 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 20452322 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33707490 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7952382/ | |||||
| 関連名称 | PMC7952382 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s41598-021-84818-1 | |||||
| 関連名称 | 10.1038/s41598-021-84818-1 | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2021 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
