{"created":"2023-06-19T10:43:35.181954+00:00","id":3827,"links":{},"metadata":{"_buckets":{"deposit":"b8ea41c1-5239-49b5-83a9-348abac1259c"},"_deposit":{"created_by":11,"id":"3827","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3827"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003827","sets":["30:202:203","30:403:404"]},"author_link":["8439","3394","8438","7211","534","7871","7358","7208","531","550"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"11","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡野, 純子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中江, 由希"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"仲川, 孝彦"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"樫, 美和子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"寺島, 智也"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"長久保, 大輔"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"鈴木, 義久"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小島, 秀人"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"33707490","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/s41598-021-84818-1"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-021-84818-1","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC7952382"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7952382/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2021"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OKANO, Junko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nakae, Yuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKAGAWA, Takahiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KATAGI, Miwako"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TERASHIMA, Tomoya"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"NAGAKUBO, Daisuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKAYAMA, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOSHIE, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUZUKI, Yoshihisa"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KOJIMA, Hideto"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-07"}],"displaytype":"detail","filename":"s41598-021-84818-1.pdf","filesize":[{"value":"9.8 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s41598-021-84818-1","url":"https://shiga-med.repo.nii.ac.jp/record/3827/files/s41598-021-84818-1.pdf"},"version_id":"c775de09-70a9-4abe-885b-be5255a6c0c9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biophysics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biotechnology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell biology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Developmental biology","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury."}]},"item_type_id":"4","owner":"11","path":["203","404"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-07"},"publish_date":"2021-04-07","publish_status":"0","recid":"3827","relation_version_is_last":true,"title":["A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:37:19.820857+00:00"}