@article{oai:shiga-med.repo.nii.ac.jp:00003827,
 author = {岡野, 純子 and 中江, 由希 and 仲川, 孝彦 and 樫, 美和子 and 寺島, 智也 and 長久保, 大輔 and 鈴木, 義久 and 小島, 秀人 and OKANO, Junko and Nakae, Yuki and NAKAGAWA, Takahiko and KATAGI, Miwako and TERASHIMA, Tomoya and NAGAKUBO, Daisuke and NAKAYAMA, Takashi and YOSHIE, Osamu and SUZUKI, Yoshihisa and KOJIMA, Hideto},
 issue = {1},
 journal = {Scientific Reports},
 month = {Mar},
 note = {pdf, Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery., Journal Article},
 title = {A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury.},
 volume = {11},
 year = {2021}
}