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Impact of 2 Gy γ-irradiation on the hallmark characteristics of human bone marrow-derived MSCs.
http://hdl.handle.net/10422/00012888
http://hdl.handle.net/10422/0001288876585b1a-947c-438d-96e3-99b8f24f875e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-01-14 | |||||
| タイトル | ||||||
| タイトル | Impact of 2 Gy γ-irradiation on the hallmark characteristics of human bone marrow-derived MSCs. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Bone | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Bone marrow mesenchymal stromal/stem cell | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ComplicationHematopoiesis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Total body irradiation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
IWASA, Masaki
× IWASA, Masaki× FUJII, Sumie× FUJISHIRO, Aya× MAEKAWA, Taira× ANDOH, Akira× TAKAORI-KONDO, Akifumi× ICHINOHE, Tatsuo× MIURA, Yasuo |
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| 著者別名 |
岩佐, 磨佐紀
× 岩佐, 磨佐紀× 藤城, 綾× 前川, 平× 安藤, 朗 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Two gray γ-irradiation is a widely employed basic module for total body irradiation (TBI) in allogeneic hematopoietic cell transplantation (HCT). The effects of γ-irradiation on hematopoietic and immune cells have been well investigated, but its effects on the bone marrow microenvironment (BMM) are unknown. Given the crucial contribution of mesenchymal/stromal stem cells (MSCs) in the BMM to hematopoiesis and osteogenesis, we investigated whether γ-irradiation affects the hallmark characteristics of human bone marrow-derived MSCs (BM-MSCs). Expansion of 2 Gy γ-irradiated BM-MSCs was delayed but eventually recovered. Colony formation and osteogenic, adipogenic, and chondrogenic differentiation capabilities of these cells were extensively suppressed. Irradiation of BM-MSCs did not affect the expansion of CD34 + hematopoietic stem and progenitor cells or production of CD11b + mature myeloid cells in co-cultures. However, it reduced production of CD19 + B-cells, as well as expression of CXCL12 and interleukin-7, which are essential for B-cell lymphopoiesis, in 2 Gy γ-irradiated BM-MSCs. Collectively, colony formation, osteogenic differentiation, and B-cell lymphopoiesis-supportive capabilities of γ-irradiated BM-MSCs were reduced. These effects may predispose survivors receiving HCT with TBI to defective bone formation and a perturbed humoral immune response. | |||||
| 書誌情報 |
en : International Journal of Hematology 発行日 2021-01-01 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33386593 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s12185-020-03072-9 | |||||
| 関連名称 | 10.1007/s12185-020-03072-9 | |||||
| 権利 | ||||||
| 権利情報 | © Japanese Society of Hematology 2021 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
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IWASA, Masaki, FUJII, Sumie, FUJISHIRO, Aya, MAEKAWA, Taira, ANDOH, Akira, TAKAORI-KONDO, Akifumi, ICHINOHE, Tatsuo, MIURA, Yasuo, 2021, Impact of 2 Gy γ-irradiation on the hallmark characteristics of human bone marrow-derived MSCs.: Springer Nature.
