{"created":"2023-06-19T10:43:32.576522+00:00","id":3778,"links":{},"metadata":{"_buckets":{"deposit":"9ed6a586-f0cf-4709-a833-5e5f1b3148cd"},"_deposit":{"created_by":11,"id":"3778","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3778"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003778","sets":["30:227:228"]},"author_link":["7172","7245","8011","8330","644","7637","8009","8008"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01-01","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"International Journal of Hematology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩佐, 磨佐紀"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"藤城, 綾"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"前川, 平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安藤, 朗"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Two gray γ-irradiation is a widely employed basic module for total body irradiation (TBI) in allogeneic hematopoietic cell transplantation (HCT). The effects of γ-irradiation on hematopoietic and immune cells have been well investigated, but its effects on the bone marrow microenvironment (BMM) are unknown. Given the crucial contribution of mesenchymal/stromal stem cells (MSCs) in the BMM to hematopoiesis and osteogenesis, we investigated whether γ-irradiation affects the hallmark characteristics of human bone marrow-derived MSCs (BM-MSCs). Expansion of 2 Gy γ-irradiated BM-MSCs was delayed but eventually recovered. Colony formation and osteogenic, adipogenic, and chondrogenic differentiation capabilities of these cells were extensively suppressed. Irradiation of BM-MSCs did not affect the expansion of CD34 + hematopoietic stem and progenitor cells or production of CD11b + mature myeloid cells in co-cultures. However, it reduced production of CD19 + B-cells, as well as expression of CXCL12 and interleukin-7, which are essential for B-cell lymphopoiesis, in 2 Gy γ-irradiated BM-MSCs. Collectively, colony formation, osteogenic differentiation, and B-cell lymphopoiesis-supportive capabilities of γ-irradiated BM-MSCs were reduced. These effects may predispose survivors receiving HCT with TBI to defective bone formation and a perturbed humoral immune response. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33386593","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1007/s12185-020-03072-9"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12185-020-03072-9","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Japanese Society of Hematology 2021"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IWASA, Masaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"FUJII, Sumie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUJISHIRO, Aya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MAEKAWA, Taira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ANDOH, Akira"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"TAKAORI-KONDO, Akifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ICHINOHE, Tatsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIURA, Yasuo"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone marrow mesenchymal stromal/stem cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ComplicationHematopoiesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Total body irradiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impact of 2 Gy γ-irradiation on the hallmark characteristics of human bone marrow-derived MSCs.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impact of 2 Gy γ-irradiation on the hallmark characteristics of human bone marrow-derived MSCs."}]},"item_type_id":"4","owner":"11","path":["228"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-14"},"publish_date":"2021-01-14","publish_status":"0","recid":"3778","relation_version_is_last":true,"title":["Impact of 2 Gy γ-irradiation on the hallmark characteristics of human bone marrow-derived MSCs."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:39:31.579340+00:00"}