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Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice.
http://hdl.handle.net/10422/00012638
http://hdl.handle.net/10422/0001263895f72abd-2d85-4a6f-85ec-853eb7c837d6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
j.isci.2020.100929 (5.5 MB)
|
©2020 The Author(s).
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-09 | |||||
| タイトル | ||||||
| タイトル | Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Developmental Genetics | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Molecular Biology | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
KADOTA, Yosuke
× KADOTA, Yosuke× JAM, Faidruz Azura× YUKIUE, Haruka× TERAKADO, Ichiro× MORIMUNE, Takao× TANO, Ayami× TANAKA, Yuya× AKAHANE, Sayumi× FUKUMURA, Mayu× TOOYAMA, Ikuo× MORI, Masaki |
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| 著者別名 |
門田, 陽介
× 門田, 陽介× 雪上, 晴加× 寺門, 一郎× 森宗, 孝夫× 田埜, 郁実× 田中, 雄也× 赤羽, 紗由美× 福村, 真優× 遠山, 育夫× 森, 雅樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The juvenile phase is characterized by continuously progressing physiological processes such as growth and maturation, which are accompanied by transitions in gene expression. The contribution of transcriptome dynamics to the establishment of juvenile properties remains unclear. Here, we investigated alternative splicing (AS) events in postnatal growth and elucidated the landscape of age-dependent alternative splicing (ADAS) in C57BL/6 mice. Our analysis of ADAS in the cerebral cortex, cardiomyocytes, and hepatocytes revealed numerous juvenile-specific splicing isoforms that shape the juvenile transcriptome, which in turn functions as a basis for the highly anabolic status of juvenile cells. Mechanistically, the juvenile-expressed splicing factor Srsf7 mediates ADAS, as exemplified by switching from juvenile to adult forms of anabolism-associated genes Eif4a2 and Rbm7. Suppression of Srsf7 results in "fast-forwarding" of this transcriptome transition, causing impaired anabolism and growth in mice. Thus, juvenile-specific AS is indispensable for the anabolic state of juveniles and differentiates juveniles from adults. | |||||
| 書誌情報 |
en : iScience 巻 23, 号 3, p. 100929, 発行日 2020-03-27 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2589-0042 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32146325 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063262/ | |||||
| 関連名称 | PMC7063262 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.isci.2020.100929 | |||||
| 関連名称 | 10.1016/j.isci.2020.100929 | |||||
| 権利 | ||||||
| 権利情報 | © 2020 The Author(s). | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
