{"created":"2023-06-19T10:43:18.085132+00:00","id":3515,"links":{},"metadata":{"_buckets":{"deposit":"eccd427c-ea98-4661-8c8f-74eb654b01c5"},"_deposit":{"created_by":11,"id":"3515","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3515"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003515","sets":["19:206:207"]},"author_link":["7347","7348","7827","7825","7491","7488","1957","7828","7826","7600","7493"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"100929","bibliographicVolumeNumber":"23","bibliographic_titles":[{},{"bibliographic_title":"iScience","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"門田, 陽介"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"雪上, 晴加"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺門, 一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森宗, 孝夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田埜, 郁実"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 雄也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"赤羽, 紗由美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福村, 真優"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"遠山, 育夫"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"森, 雅樹"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The juvenile phase is characterized by continuously progressing physiological processes such as growth and maturation, which are accompanied by transitions in gene expression. The contribution of transcriptome dynamics to the establishment of juvenile properties remains unclear. Here, we investigated alternative splicing (AS) events in postnatal growth and elucidated the landscape of age-dependent alternative splicing (ADAS) in C57BL/6 mice. Our analysis of ADAS in the cerebral cortex, cardiomyocytes, and hepatocytes revealed numerous juvenile-specific splicing isoforms that shape the juvenile transcriptome, which in turn functions as a basis for the highly anabolic status of juvenile cells. Mechanistically, the juvenile-expressed splicing factor Srsf7 mediates ADAS, as exemplified by switching from juvenile to adult forms of anabolism-associated genes Eif4a2 and Rbm7. Suppression of Srsf7 results in \"fast-forwarding\" of this transcriptome transition, causing impaired anabolism and growth in mice. Thus, juvenile-specific AS is indispensable for the anabolic state of juveniles and differentiates juveniles from adults.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"32146325","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.isci.2020.100929"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.isci.2020.100929","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC7063262"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063262/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author(s)."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2589-0042","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KADOTA, Yosuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"JAM, Faidruz Azura"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YUKIUE, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TERAKADO, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MORIMUNE, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANO, Ayami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANAKA, Yuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"AKAHANE, Sayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUKUMURA, Mayu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOOYAMA, Ikuo"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MORI, Masaki"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-09"}],"displaytype":"detail","filename":"j.isci.2020.100929.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","license_note":"©2020 The Author(s).\nThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).\n","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"j.isci.2020.100929","url":"https://shiga-med.repo.nii.ac.jp/record/3515/files/j.isci.2020.100929.pdf"},"version_id":"532ddb27-7dd0-40b0-9f5a-7a595d8996e0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Developmental Genetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Molecular Biology","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice."}]},"item_type_id":"4","owner":"11","path":["207"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-09"},"publish_date":"2020-04-09","publish_status":"0","recid":"3515","relation_version_is_last":true,"title":["Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T12:21:19.596757+00:00"}