WEKO3
-
RootNode
アイテム
Vimentin Expression in Tumor Microenvironment Predicts Survival in Pancreatic Ductal Adenocarcinoma: Heterogeneity in Fibroblast Population.
http://hdl.handle.net/10422/00012581
http://hdl.handle.net/10422/000125814b5f13fb-3a17-4c04-995d-04d7bc7acfe1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
s10434-019-07891-x (242.4 kB)
|
© Society of Surgical Oncology 2019
|
|
Supplementary material (1.1 MB)
|
© Society of Surgical Oncology 2019
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2019-11-26 | |||||||
| タイトル | ||||||||
| タイトル | Vimentin Expression in Tumor Microenvironment Predicts Survival in Pancreatic Ductal Adenocarcinoma: Heterogeneity in Fibroblast Population. | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
MAEHIRA, Hiromitsu
× MAEHIRA, Hiromitsu× MIYAKE, Toru× IIDA, Hiroya× TOKUDA, Aya× MORI, Haruki× YASUKAWA, Daiki× MUKAISHO, Ken-ichi× SHIMIZU, Tomoharu× TANI, Masaji |
|||||||
| 著者別名 |
前平, 博充
× 前平, 博充× 三宅, 亨× 飯田, 洋也× 徳田, 彩× 森, 治樹
× 安川, 大貴× 向所, 賢一× 清水, 智治× 谷, 眞至 |
|||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | BACKGROUND:The tumor microenvironment, including cancer-associated fibroblasts (CAFs), plays various clinical roles in cancer growth. CAFs are a heterogeneous population and express a variety of mesenchymal markers. However, the clinical roles for CAFs expressing different markers in pancreatic ductal adenocarcinoma (PDAC) remain unknown. METHODS:We reviewed 67 resected PDAC patients who had not received preoperative therapy. Each primary tumor was analyzed for vimentin and α-smooth muscle actin (α-SMA) expression by immunohistochemical and dual immunofluorescence staining. RESULTS:There was no correlation between the percentage of cells expressing vimentin and α-SMA in the tumor stroma (Pearson's correlation coefficient: r = 0.171). Higher vimentin expression (p = 0.018) was associated with significantly shorter overall survival in PDAC patients. Using dual immunofluorescence staining, vimentin-positive CAFs were divided into two subpopulations: co-expression of α-SMA, and no co-expression of α-SMA. In PDAC, the level of co-expression had no effect on survival using univariate analysis (median survival time, 33.3 months for low co-expression vs. 18.2 months for high co-expression; log-rank, p = 0.143). However, multivariate analysis clarified that CAFs expressing vimentin alone was an independent predictor of poor survival (p = 0.014; hazard ratio, 2.305; 95% confidence interval, 1.181-4.497). CONCLUSIONS:Vimentin-positive CAFs without co-expression of α-SMA were associated with poor survival in PDAC, and CAFs possessed molecular and functional heterogeneity in this disease. |
|||||||
| 言語 | en | |||||||
| 書誌情報 |
en : Annals of surgical oncology 巻 26, 号 13, p. 4791-4804, 発行日 2019-12 |
|||||||
| 出版者 | ||||||||
| 出版者 | Springer International Publishing | |||||||
| 言語 | en | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1534-4681 | |||||||
| PMID | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 31583548 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1245/s10434-019-07891-x | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報 | © Society of Surgical Oncology 2019 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 関係URI | ||||||||
| 識別子タイプ | HDL | |||||||
| 関連識別子 | http://hdl.handle.net/10422/00012688 | |||||||
| 関連名称 | 博士論文要旨 | |||||||
