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Juvenility-associated lncRNA Gm14230 maintains cellular juvenescence.
http://hdl.handle.net/10422/00012494
http://hdl.handle.net/10422/00012494e22c7f75-f80d-4875-b3fb-f16b3f46701b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jcs.227801 (7.6 MB)
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© 2019. Published by The Company of Biologists Ltd
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-16 | |||||
| タイトル | ||||||
| タイトル | Juvenility-associated lncRNA Gm14230 maintains cellular juvenescence. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Bioinformatics | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cell biology | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cellular juvenescence | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Long noncoding RNA | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Transcriptional regulation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
TANO, Ayami
× TANO, Ayami× KADOTA, Yosuke× MORIMUNE, Takao× JAM, Faidruz Azura Binti× YUKIUE, Haruka× BELLIER, Jean-Pierre× SOKODA, Tatsuyuki× MARUO, Yoshihiro× TOOYAMA, Ikuo× MORI, Masaki |
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| 著者別名 |
田埜, 郁実
× 田埜, 郁実× 門田, 陽介× 森宗, 孝夫× 雪上, 晴加× 底田, 辰之× 丸尾, 良浩× 遠山, 育夫× 森, 雅樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Juvenile animals possess distinct properties that are missing in adults. These properties include capabilities for higher growth, faster wound healing, plasticity and regeneration. However, the molecular mechanisms underlying these juvenile physiological properties are not fully understood. To obtain insight into the distinctiveness of juveniles from adults at the molecular level, we assessed long noncoding RNAs (lncRNAs) that are highly expressed selectively in juvenile cells. The noncoding elements of the transcriptome were investigated in hepatocytes and cardiomyocytes isolated from juvenile and adult mice. Here, we identified 62 juvenility-associated lncRNAs (JAlncs), which are selectively expressed in both hepatocytes and cardiomyocytes from juvenile mice. Among these common (shared) JAlncs, Gm14230 is evolutionarily conserved and is essential for cellular juvenescence. Loss of Gm14230 impairs cell growth and causes cellular senescence. Gm14230 safeguards cellular juvenescence through recruiting the histone methyltransferase Ezh2 to Tgif2, thereby repressing the functional role of Tgif2 in cellular senescence. Thus, we identify Gm14230 as a juvenility-selective lncRNA required to maintain cellular juvenescence. | |||||
| 書誌情報 |
en : Journal of Cell Science 発行日 2019-04-16 |
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| 出版者 | ||||||
| 出版者 | The Company of Biologists | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1477-9137 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30872457 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1242/jcs.227801 | |||||
| 権利 | ||||||
| 権利情報 | © 2019. Published by The Company of Biologists Ltd | |||||
| 権利 | ||||||
| 権利情報 | The full-text file will be made open to the public on 16 April 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
