@article{oai:shiga-med.repo.nii.ac.jp:00003362,
 author = {田埜, 郁実 and 門田, 陽介 and 森宗, 孝夫 and 雪上, 晴加 and 底田, 辰之 and 丸尾, 良浩 and 遠山, 育夫 and 森, 雅樹 and TANO, Ayami and KADOTA, Yosuke and MORIMUNE, Takao and JAM, Faidruz Azura Binti and YUKIUE, Haruka and BELLIER, Jean-Pierre and SOKODA, Tatsuyuki and MARUO, Yoshihiro and TOOYAMA, Ikuo and MORI, Masaki},
 journal = {Journal of Cell Science},
 month = {Apr},
 note = {Juvenile animals possess distinct properties that are missing in adults. These properties include capabilities for higher growth, faster wound healing, plasticity and regeneration. However, the molecular mechanisms underlying these juvenile physiological properties are not fully understood. To obtain insight into the distinctiveness of juveniles from adults at the molecular level, we assessed long noncoding RNAs (lncRNAs) that are highly expressed selectively in juvenile cells. The noncoding elements of the transcriptome were investigated in hepatocytes and cardiomyocytes isolated from juvenile and adult mice. Here, we identified 62 juvenility-associated lncRNAs (JAlncs), which are selectively expressed in both hepatocytes and cardiomyocytes from juvenile mice. Among these common (shared) JAlncs, Gm14230 is evolutionarily conserved and is essential for cellular juvenescence. Loss of Gm14230 impairs cell growth and causes cellular senescence. Gm14230 safeguards cellular juvenescence through recruiting the histone methyltransferase Ezh2 to Tgif2, thereby repressing the functional role of Tgif2 in cellular senescence. Thus, we identify Gm14230 as a juvenility-selective lncRNA required to maintain cellular juvenescence., Journal Article},
 title = {Juvenility-associated lncRNA Gm14230 maintains cellular juvenescence.},
 year = {2019}
}