{"created":"2023-06-19T10:43:11.584153+00:00","id":3362,"links":{},"metadata":{"_buckets":{"deposit":"04c9d275-346f-42f7-8c5c-66295d499948"},"_deposit":{"created_by":11,"id":"3362","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3362"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003362","sets":["19:206:207"]},"author_link":["7347","7348","6573","7495","7491","7488","1957","7600","2869","7493"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-04-16","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"Journal of Cell Science","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田埜, 郁実"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"門田, 陽介"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"森宗, 孝夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"雪上, 晴加 "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"底田, 辰之"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"丸尾, 良浩"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"遠山, 育夫"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"森, 雅樹"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Juvenile animals possess distinct properties that are missing in adults. These properties include capabilities for higher growth, faster wound healing, plasticity and regeneration. However, the molecular mechanisms underlying these juvenile physiological properties are not fully understood. To obtain insight into the distinctiveness of juveniles from adults at the molecular level, we assessed long noncoding RNAs (lncRNAs) that are highly expressed selectively in juvenile cells. The noncoding elements of the transcriptome were investigated in hepatocytes and cardiomyocytes isolated from juvenile and adult mice. Here, we identified 62 juvenility-associated lncRNAs (JAlncs), which are selectively expressed in both hepatocytes and cardiomyocytes from juvenile mice. Among these common (shared) JAlncs, Gm14230 is evolutionarily conserved and is essential for cellular juvenescence. Loss of Gm14230 impairs cell growth and causes cellular senescence. Gm14230 safeguards cellular juvenescence through recruiting the histone methyltransferase Ezh2 to Tgif2, thereby repressing the functional role of Tgif2 in cellular senescence. Thus, we identify Gm14230 as a juvenility-selective lncRNA required to maintain cellular juvenescence.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Company of Biologists"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"30872457","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1242/jcs.227801","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019. Published by The Company of Biologists Ltd"},{"subitem_rights":"The full-text file will be made open to the public on 16 April  2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1477-9137","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TANO, Ayami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KADOTA, Yosuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MORIMUNE, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"JAM, Faidruz Azura Binti"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YUKIUE, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"BELLIER, Jean-Pierre"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SOKODA, Tatsuyuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MARUO, Yoshihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TOOYAMA, Ikuo"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MORI, Masaki"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-16"}],"displaytype":"detail","filename":"jcs.227801.pdf","filesize":[{"value":"7.6 MB"}],"format":"application/pdf","license_note":"© 2019. Published by The Company of Biologists Ltd","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jcs.227801","url":"https://shiga-med.repo.nii.ac.jp/record/3362/files/jcs.227801.pdf"},"version_id":"2ca57946-47a7-48dd-a533-eae29799bc87"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bioinformatics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell biology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cellular juvenescence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Long noncoding RNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transcriptional regulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Juvenility-associated lncRNA Gm14230 maintains cellular juvenescence.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Juvenility-associated lncRNA Gm14230 maintains cellular juvenescence."}]},"item_type_id":"4","owner":"11","path":["207"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-16"},"publish_date":"2019-04-16","publish_status":"0","recid":"3362","relation_version_is_last":true,"title":["Juvenility-associated lncRNA Gm14230 maintains cellular juvenescence."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:31:44.339991+00:00"}