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Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.
http://hdl.handle.net/10422/00012946
http://hdl.handle.net/10422/00012946713f2ae6-8c67-4646-b500-edc60769d047
名前 / ファイル | ライセンス | アクション |
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JAD-201174 (4.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-04-13 | |||||
タイトル | ||||||
タイトル | Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Alzheimer’s disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | amyloid-β | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ILEI | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neurotransmitter receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | synapse | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
NAKANO, Masaki
× NAKANO, Masaki× MITSUISHI, Yachiyo× LIU, Lei× WATANABE, Naoki× HIBINO, Emi× HATA, Saori× SAITO, Takashi× SAIDO, Takaomi C× MURAYAMA, Shigeo× KASUGA, Kensaku× IKEUCHI, Takeshi× SUZUKI, Toshiharu× NISHIMURA, Masaki |
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著者別名 |
中野, 将希
× 中野, 将希× 三ツ石, 弥千代× 渡邊, 直希× 日比野, 絵美× 西村, 正樹 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Brain amyloid-β (Aβ) peptide is released into the interstitial fluid (ISF) in a neuronal activity-dependent manner, and Aβ deposition in Alzheimer's disease (AD) is linked to baseline neuronal activity. Although the intrinsic mechanism for Aβ generation remains to be elucidated, interleukin-like epithelial-mesenchymal transition inducer (ILEI) is a candidate for an endogenous Aβ suppressor. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: This study aimed to access the mechanism underlying ILEI secretion and its effect on Aβ production in the brain. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods: ILEI and Aβ levels in the cerebral cortex were monitored using a newly developed ILEI-specific ELISA and in vivo microdialysis in mutant human Aβ precursor protein-knockin mice. ILEI levels in autopsied brains and cerebrospinal fluid (CSF) were measured using ELISA. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: Extracellular release of ILEI and Aβ was dependent on neuronal activation and specifically on tetanus toxin-sensitive exocytosis of synaptic vesicles. However, simultaneous monitoring of extracellular ILEI and Aβ revealed that a spontaneous fluctuation of ILEI levels appeared to inversely mirror that of Aβ levels. Selective activation and inhibition of synaptic receptors differentially altered these levels. The evoked activation of AMPA-type receptors resulted in opposing changes to ILEI and Aβ levels. Brain ILEI levels were selectively decreased in AD. CSF ILEI concentration correlated with that of Aβ and were reduced in AD and mild cognitive impairment. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: ILEI and Aβ are released from distinct subpopulations of synaptic terminals in an activity-dependent manner, and ILEI negatively regulates Aβ production in specific synapse types. CSF ILEI might represent a surrogate marker for the accumulation of brain Aβ. |
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書誌情報 |
en : Journal of Alzheimer's disease : JAD 巻 80, 号 1, p. 159-174, 発行日 2021-03-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1875-8908 | |||||
PMID | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 33492290 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3233/jad-201174 | |||||
関連名称 | 10.3233/JAD-201174 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |