{"created":"2023-06-19T10:43:35.570713+00:00","id":3836,"links":{},"metadata":{"_buckets":{"deposit":"43c18a78-1a9f-42ad-876e-997a364f75e2"},"_deposit":{"created_by":11,"id":"3836","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3836"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003836","sets":["19:219:220"]},"author_link":["2568","2564","8460","8461","8463","7973","2575","8465","8462","8466","2545","8459","8464"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"174","bibliographicPageStart":"159","bibliographicVolumeNumber":"80","bibliographic_titles":[{},{"bibliographic_title":"Journal of Alzheimer's disease : JAD","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中野, 将希"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"三ツ石, 弥千代"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡邊, 直希"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"日比野, 絵美"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"西村, 正樹"}],"nameIdentifiers":[{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:\nBrain amyloid-β (Aβ) peptide is released into the interstitial fluid (ISF) in a neuronal activity-dependent manner, and Aβ deposition in Alzheimer's disease (AD) is linked to baseline neuronal activity. Although the intrinsic mechanism for Aβ generation remains to be elucidated, interleukin-like epithelial-mesenchymal transition inducer (ILEI) is a candidate for an endogenous Aβ suppressor. ","subitem_description_type":"Abstract"},{"subitem_description":"Objective:\nThis study aimed to access the mechanism underlying ILEI secretion and its effect on Aβ production in the brain. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nILEI and Aβ levels in the cerebral cortex were monitored using a newly developed ILEI-specific ELISA and in vivo microdialysis in mutant human Aβ precursor protein-knockin mice. ILEI levels in autopsied brains and cerebrospinal fluid (CSF) were measured using ELISA. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nExtracellular release of ILEI and Aβ was dependent on neuronal activation and specifically on tetanus toxin-sensitive exocytosis of synaptic vesicles. However, simultaneous monitoring of extracellular ILEI and Aβ revealed that a spontaneous fluctuation of ILEI levels appeared to inversely mirror that of Aβ levels. Selective activation and inhibition of synaptic receptors differentially altered these levels. The evoked activation of AMPA-type receptors resulted in opposing changes to ILEI and Aβ levels. Brain ILEI levels were selectively decreased in AD. CSF ILEI concentration correlated with that of Aβ and were reduced in AD and mild cognitive impairment. ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion:\nILEI and Aβ are released from distinct subpopulations of synaptic terminals in an activity-dependent manner, and ILEI negatively regulates Aβ production in specific synapse types. CSF ILEI might represent a surrogate marker for the accumulation of brain Aβ. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"33492290","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3233/JAD-201174"}],"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3233/jad-201174","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1875-8908","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKANO, Masaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MITSUISHI, Yachiyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"LIU, Lei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WATANABE, Naoki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HIBINO, Emi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"HATA, Saori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAITO, Takashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SAIDO, Takaomi C"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MURAYAMA, Shigeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KASUGA, Kensaku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IKEUCHI, Takeshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SUZUKI, Toshiharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIMURA, Masaki"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-13"}],"displaytype":"detail","filename":"JAD-201174.pdf","filesize":[{"value":"4.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JAD-201174","url":"https://shiga-med.repo.nii.ac.jp/record/3836/files/JAD-201174.pdf"},"version_id":"bd4d6353-322a-41f2-99d4-7c54e7529c74"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alzheimer’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amyloid-β","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ILEI","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurotransmitter receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"synapse","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations."}]},"item_type_id":"4","owner":"11","path":["220"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-13"},"publish_date":"2021-04-13","publish_status":"0","recid":"3836","relation_version_is_last":true,"title":["Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:37:10.273737+00:00"}