Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2023-06-06 |
タイトル |
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タイトル |
IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
IDH wild type |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Lower-grade glioma |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
TERT promoter mutation |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Molecular glioblastoma |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
著者 |
NAKASU, Satoshi
DEGUCHI, Shoichi
NAKASU, Yoko
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著者別名 |
中洲, 敏
中洲, 庸子
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The WHO 2021 classification defines IDH wild type (IDHw) histologically lower-grade glioma (hLGG) as molecular glioblastoma (mGBM) if TERT promoter mutation (pTERTm), EGFR amplification or chromosome seven gain and ten loss aberrations are indicated. We systematically reviewed articles of IDHw hLGGs studies (49 studies, N = 3748) and meta-analyzed mGBM prevalence and overall survival (OS) according to the PRISMA statement. mGBM rates in IDHw hLGG were significantly lower in Asian regions (43.7%, 95% confidence interval [CI: 35.8-52.0]) when compared to non-Asian regions (65.0%, [CI: 52.9-75.4]) (P = 0.005) and were significantly lower in fresh-frozen specimen when compared to formalin-fixed paraffin-embedded samples (P = 0.015). IDHw hLGGs without pTERTm rarely expressed other molecular markers in Asian studies when compared to non-Asian studies. Patients with mGBM had significantly longer OS times when compared to histological GBM (hGBM) (pooled hazard ratio (pHR) 0.824, [CI: 0.694-0.98], P = 0.03)). In patients with mGBM, histological grade was a significant prognostic factor (pHR 1.633, [CI: 1.09-2.447], P = 0.018), as was age (P = 0.001) and surgical extent (P = 0.018). Although bias risk across studies was moderate, mGBM with grade II histology showed better OS rates when compared to hGBM. |
書誌情報 |
en : Brain Tumor Pathology
発行日 2023-05-22
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出版者 |
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出版者 |
Springer Nature |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1433-7398 |
PMID |
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識別子タイプ |
PMID |
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関連識別子 |
37212969 |
DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s10014-023-00463-8 |
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関連名称 |
10.1007/s10014-023-00463-8 |
権利 |
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権利情報 |
© 2023. The Author(s), under exclusive licence to The Japan Society of Brain Tumor Pathology. |
資源タイプ |
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内容記述タイプ |
Other |
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内容記述 |
Journal Article |