{"_buckets": {"deposit": "ff27b465-ee53-479e-a446-c1cc76e90540"}, "_deposit": {"created_by": 11, "id": "4476", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "4476"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00004476", "sets": ["79", "228", "294"]}, "author_link": ["2890", "706", "675", "7646", "644", "674", "7639", "7156", "7509", "8708", "677"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2023-03-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "418", "bibliographicPageStart": "412", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{}, {"bibliographic_title": "Biological \u0026 pharmaceutical bulletin", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "磯野, 哲一郎"}], 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In addition, the accuracy of TaqMan PCR to assess these two polymorphisms has not been investigated. In this study, we evaluated TaqMan PCR for detection of the NUDT15 single-nucleotide polymorphisms (SNPs) and examined the clinical impact of Arg139His on thiopurine-induced leukopenia. First, we demonstrated that a TaqMan PCR assay successfully detected the Arg139His polymorphism of NUDT15 in clinical samples. Next, the NUDT15 gene polymorphisms (Arg139Cys and Arg139His) were separately analyzed by TaqMan Real-Time PCR in 189 patients from August 2018 to July 2019. The incidences of leukopenia within 2 years were 16.2, 57.9, and 100% for arginine (Arg)/Arg, Arg/cysteine (Cys), and Arg/histidine (His), respectively. The leukopenia was significantly increased in Arg/Cys and Arg/His compared with Arg/Arg. This retrospective clinical study indicated that, in addition to Arg139Cys, Arg139His may be clinically associated with a high risk of leukopenia. Pharmacogenomics will help in selecting drugs and determining the individualized dosage of thiopurine drugs.", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Pharmaceutical Society of Japan"}]}, "item_4_publisher_34": {"attribute_name": "別言語の出版者", "attribute_value_mlt": [{"subitem_publisher": "日本薬学会"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "36858569", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1248/bpb.b22-00686"}], "subitem_relation_type": "isIdenticalTo", 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"attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Single-Nucleotide Polymorphisms, c.415C \u003e T (Arg139Cys) and c.416G \u003e A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Single-Nucleotide Polymorphisms, c.415C \u003e T (Arg139Cys) and c.416G \u003e A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia."}]}, "item_type_id": "4", "owner": "11", "path": ["79", "228", "294"], "permalink_uri": "http://hdl.handle.net/10422/00013551", "pubdate": {"attribute_name": "公開日", "attribute_value": "2023-04-27"}, "publish_date": "2023-04-27", "publish_status": "0", "recid": "4476", "relation": {}, "relation_version_is_last": true, "title": ["Single-Nucleotide Polymorphisms, c.415C \u003e T (Arg139Cys) and c.416G \u003e A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia."], "weko_shared_id": -1}