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Immunohistochemical and clinicopathological study regarding nardilysin on extramammary Paget's disease
http://hdl.handle.net/10422/00013525
http://hdl.handle.net/10422/0001352561563d5f-be13-47f5-8a21-eb14cac6f376
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-03-31 | |||||
| タイトル | ||||||
| タイトル | Immunohistochemical and clinicopathological study regarding nardilysin on extramammary Paget's disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Extramammary Paget's disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Nardilysin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | p53 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
YAMAGUCHI, Akihiko
× YAMAGUCHI, Akihiko× TAKAHASHI, Toshifumi× KATO, Takeshi× TANAKA, Toshihiro× NISHI, Eiichiro× FUJIMOTO, Noriki |
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| 著者別名 |
山口, 明彦
× 山口, 明彦× 高橋, 聡文× 加藤, 威× 田中, 俊宏× 西, 英一郎× 藤本, 徳毅 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It has been reported that nardilysin (NRDC), a metalloendopeptidase which regulates various growth factors and cytokines, is associated with malignancies in a conflicting manner, in which it promoted gastric, hepatocellular, and colorectal cancers and suppressed pancreatic ductal adenocarcinoma. However, it has not been investigated how NRDC is associated with cutaneous malignancies for now. Immunohistochemical staining has revealed that NRDC expression is observed in all extramammary Paget's disease (EMPD) cases. Notably, other cutaneous malignancies including basal cell carcinoma, squamous cell carcinoma, and eccrine porocarcinoma, did not show increased NRDC expression in immunohistochemistry. EMPD typically presents several types of lesions including nodules, and positive staining of NRDC on EMPD was observed regardless of the type of lesions. Examination using samples taken from nodular lesions showed that some cases showed heterogenous NRDC expression within each lesion. We also found that NRDC staining was weaker in the marginal parts of EMPD lesion than in the central parts in several cases, and tumor cells tend to be distributed beyond the macroscopic skin lesions in these cases. It was speculated that decreased NRDC expression in the marginal zones of the skin lesions may be associated with the ability of tumor cells to produce the cutaneous manifestation of EMPD. This study suggests that NRDC may be associated with EMPD like other malignancies reported previously. | |||||
| 書誌情報 |
en : Archives of Dermatological Research 発行日 2023-03-03 |
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| 出版者 | ||||||
| 出版者 | Institute for Ionics | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0340-3696 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 36867223 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s00403-023-02579-5 | |||||
| 関連名称 | 10.1007/s00403-023-02579-5 | |||||
| 権利 | ||||||
| 権利情報 | © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
