WEKO3
アイテム
Plasmalogen in the brain: Effects on cognitive functions and behaviors attributable to its properties.
http://hdl.handle.net/10422/00013407
http://hdl.handle.net/10422/00013407d7e0162d-0396-48ac-8fd7-6fed2d9dfdec
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2022-09-16 | |||||||||
タイトル | ||||||||||
タイトル | Plasmalogen in the brain: Effects on cognitive functions and behaviors attributable to its properties. | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Behavior | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Delivery | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Neurological disorders | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Plasmalogen | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
UDAGAWA, Jun
× UDAGAWA, Jun
× HINO, Kodai
|
|||||||||
著者別名 |
宇田川, 潤
× 宇田川, 潤
|
|||||||||
抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Ether phospholipid compositions are altered in the plasma or brain of patients with brain disorders, such as Alzheimer and Parkinson's disease, including those with psychiatric disorders like schizophrenia and bipolar disorders. Notably, plasmenyl ethanolamine has a unique chemical structure, i.e., a vinyl-ether bond at the sn-1 position, which mainly links with polyunsaturated fatty acids (PUFAs) at the sn-2 position. Those characteristic moieties give plasmalogen molecules unique biophysical and chemical properties that modulate membrane trafficking, lipid rafts, intramolecular PUFA moieties, and oxidative states. Previous reports suggested that a deficiency in plasmenyl ethanolamine leads to disturbances of the myelin structure, synaptic neurotransmission and intracellular signaling, apoptosis of neurons, and neuroinflammation, accompanied by cognitive disturbances and aberrant behaviors like hyperactivity in mice. Therefore, this review summarizes the relationship between the biological functions of plasmalogen. We also proposed biophysical properties that alter brain phospholipid compositions related to aberrant behaviors and cognitive dysfunction. Finally, a brief review of possible remedial plasmalogen replacement therapies for neurological, psychiatric, and developmental disorders attributable to disturbed plasmalogen compositions in the organs and cells was conducted. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | erratum: Figure 1 Chemical structure of the phospholipids. Diacy (A, B) and ether (C,D) phospholipids are shown. Phosphatidylcholine (A) and phosphatidylethanolamine (B) have an ester bond at the sn-1 and sn-2 glycerol backbone positions (A, B), plasmanylethanolamine has an ether bondbat the sn-1 postion (C), and plasmenylethanolamine has a vinyl-ether bond at the sn-1 position (D). Red rectangles indicate an ester, ether, or vinyl-ether bond at the sn-1. Blue rectangles indicate hydrophilic head groups. |
|||||||||
書誌情報 |
en : Brain research bulletin 巻 188, p. 197-202, 発行日 2022 |
|||||||||
出版者 | ||||||||||
出版者 | Elsevier | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1873-2747 | |||||||||
PMID | ||||||||||
関連タイプ | isVersionOf | |||||||||
識別子タイプ | PMID | |||||||||
関連識別子 | 35970332 | |||||||||
DOI | ||||||||||
関連タイプ | isVersionOf | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.1016/j.brainresbull.2022.08.008 | |||||||||
関連名称 | 10.1016/j.brainresbull.2022.08.008 | |||||||||
権利 | ||||||||||
権利情報 | © 2022 Elsevier Inc. All rights reserved. | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | ||||||||||
著者版フラグ | ||||||||||
出版タイプ | AM | |||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
資源タイプ | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | Journal Article |