{"_buckets": {"deposit": "76fc5485-165a-4aa6-9b24-570cfc6d0207"}, "_deposit": {"created_by": 11, "id": "4314", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "4314"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00004314", "sets": ["228"]}, "author_link": ["644", "7639"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-07-28", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "8", "bibliographicPageStart": "1", "bibliographic_titles": [{}, {"bibliographic_title": "Digestion", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "安藤, 朗"}], "nameIdentifiers": [{"nameIdentifier": "644", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252395"}, {"nameIdentifier": "0000-0001-8533-2669", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8533-2669"}]}, {"creatorNames": [{"creatorName": "西田, 淳史"}], "nameIdentifiers": [{"nameIdentifier": "7639", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90719915", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90719915"}, {"nameIdentifier": "0000-0002-1288-3272", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-1288-3272"}]}]}, "item_4_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "pdf", "subitem_description_type": "Other"}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background:\nAlteration of the gut microbial structure and function (dysbiosis) is associated with the pathogenesis of various disorders including inflammatory bowel disease (IBD). ", "subitem_description_type": "Abstract"}, {"subitem_description": "Summary:\nUnder normal conditions, β-oxidation of butyrate consumes oxygen in colonocytes and maintains the anaerobic environment in the lumen. Depletion of butyrate-producing bacteria results in anaerobic glycolysis in colonocytes and increases oxygen diffusion into the lumen, leading to a luminal facultative anaerobe expansion. Dysbiosis in IBD is characterized by the reduced abundance of the phylum Firmicutes (e.g., Faecalibacterium, Roseburia, and Ruminococcus) and an increase of the phylum Proteobacteria (e.g., Enterobacteriaceae). The overall structure of the gut mycobiome differs markedly in IBD patients, particularly Crohn\u0027s disease (CD), compared with healthy individuals. An increase in the genus Candida is a major contributory factor in the alteration of the mycobiome in Japanese CD patients, but an increase in the genus Saccharomyces is characteristic in Western patients. The gut virome, which is mainly composed of bacteriophages (phages), influences gut homeostasis and pathogenic conditions via an interaction with the gut bacterial community. Alterations in the gut virome have been suggested in patients with IBD. This may alter either the immunogenicity of bacteria, thus affecting the bacteria-host interactions, or the bacterial functions such as antibiotic resistance and toxin synthesis. ", "subitem_description_type": "Abstract"}, {"subitem_description": "Key message:\nAdvances in DNA sequencing technology and bioinformatics have revolutionized our understanding of the microbiome in the gut. ", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "S. Karger AG"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "35901721", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1159/000525925"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1159/000525925", "subitem_relation_type_select": "DOI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2022 The Author(s). Published by S. Karger AG, Basel. "}]}, "item_4_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1421-9867", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ANDOH, Akira"}], "nameIdentifiers": [{"nameIdentifier": "644", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252395"}, {"nameIdentifier": "0000-0001-8533-2669", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8533-2669"}]}, {"creatorNames": [{"creatorName": "NISHIDA, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "7639", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90719915", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90719915"}, {"nameIdentifier": "0000-0002-1288-3272", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-1288-3272"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-08-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "000525925.pdf", "filesize": [{"value": "552.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is an Open Access article licensed under the Creative Commons\nAttribution-NonCommercial-4.0 International License (CC BY-NC)\n(http://www.karger.com/Services/OpenAccessLicense), applicable to\nthe online version of the article only. Usage and distribution for commercial purposes requires written permission.", "licensetype": "license_free", "mimetype": "application/pdf", "size": 552500.0, "url": {"label": "000525925", "url": "https://shiga-med.repo.nii.ac.jp/record/4314/files/000525925.pdf"}, "version_id": "0c66084a-f2ab-40bf-b5f0-061b27a85ad1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Short-chain fatty acids", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Butyrate", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mycobiome", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Virome", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Alteration of the Gut Microbiome in Inflammatory Bowel Disease.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Alteration of the Gut Microbiome in Inflammatory Bowel Disease."}]}, "item_type_id": "4", "owner": "11", "path": ["228"], "permalink_uri": "http://hdl.handle.net/10422/00013395", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-08-22"}, "publish_date": "2022-08-22", "publish_status": "0", "recid": "4314", "relation": {}, "relation_version_is_last": true, "title": ["Alteration of the Gut Microbiome in Inflammatory Bowel Disease."], "weko_shared_id": -1}