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Nasal polyp fibroblasts (NPFs)-derived exosomes are important for the release of vascular endothelial growth factor from cocultured eosinophils and NPFs.
http://hdl.handle.net/10422/00013137
http://hdl.handle.net/10422/00013137b1a99a9c-27b9-4050-8502-348e2b3e09d3
名前 / ファイル | ライセンス | アクション |
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j.anl.2021.10.002 (486.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-24 | |||||
タイトル | ||||||
タイトル | Nasal polyp fibroblasts (NPFs)-derived exosomes are important for the release of vascular endothelial growth factor from cocultured eosinophils and NPFs. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Nasal polyps | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Eosinophils | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Fibroblasts | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Coculture | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Exosome | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Vascular endothelial growth factor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SHIMIZU, Shino
× SHIMIZU, Shino× TOJIMA, Ichiro× NAKAMURA, Keigo× ARAI, Hiroyuki× KOUZAKI, Hideaki× SHIMIZU, Takeshi |
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著者別名 |
清水, 志乃
× 清水, 志乃× 戸嶋, 一郎× 中村, 圭吾× 新井, 宏幸× 神前, 英明× 清水, 猛史 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Significant eosinophil infiltration and tissue remodeling are common characteristics of conditions associated with chronic airway inflammation, such as chronic rhinosinusitis with nasal polyp and bronchial asthma. This study was designed to elucidate the role of eosinophil-fibroblast interactions in tissue remodeling during chronic airway inflammation. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods: Peripheral blood eosinophils or EoL-1 eosinophilic leukemia cells were cocultured with nasal polyp fibroblasts (NPFs). Coculture-induced release of exosomes, major components of extracellular vesicles (EVs), and a profibrotic cytokine, vascular endothelial growth factor (VEGF), were evaluated by enzyme-linked immunosorbent assay. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: Eosinophil-NPF interactions stimulated the release of exosomes and VEGF into culture supernatants. Coculture-induced release of exosomes was stimulated earlier than VEGF release, at 3 h of incubation. The average size of the EVs released by NPFs was 133 ± 3.6 nm. NPF-derived EVs (exosome concentration: 25 pg/mL) significantly stimulated VEGF release from EoL-1 cells. Pretreatment of NPFs with exosome inhibitor, GW4869 or DMA attenuated the release of exosomes and VEGF from cocultured EoL-1 cells and NPFs. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: The results of this study indicate that eosinophil-fibroblast interactions are important in the pathophysiology of tissue remodeling in eosinophil-predominant airway inflammation and that NPF-derived exosomes play a crucial role in the release of VEGF. |
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書誌情報 |
en : Auris, nasus, larynx 発行日 2021-11-01 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1879-1476 | |||||
PMID | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 34736807 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.anl.2021.10.002 | |||||
関連名称 | 10.1016/j.anl.2021.10.002 | |||||
権利 | ||||||
権利情報 | © 2021. Published by Elsevier B.V. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |