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Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice.
http://hdl.handle.net/10422/00013020
http://hdl.handle.net/10422/00013020fef87c9d-5252-4483-997f-f18cb7a51a4f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
j.jbc.2021.100761 (6.1 MB)
|
This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/). |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-06-09 | |||||
| タイトル | ||||||
| タイトル | Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Rho | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | complement | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | diabetic nephropathy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | heart failure | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | peptidase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | peptides | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | permeability | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
KOMENO, Masahiro
× KOMENO, Masahiro× PANG, Xiaoling× SHIMIZU, Akio× MOLLA, Md Rasel× YASUDA-YAMAHARA, Mako× KUME, Shinji× RAHMAN, Nor Idayu A.× SOH, Joanne Ern Chi× NGUYEN, Le Kim Chi× Ahmat Amin, Mohammad Khusni Bin× KOKAMI, Nao× SATO, Akira× ASANO, Yoshihiro× MAEGAWA, Hiroshi× 扇田, 久和 |
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| 著者別名 |
米野, 雅大
× 米野, 雅大× 清水, 昭男× 山原, 真子× 久米, 真司× 鴻上, 奈央× 佐藤, 朗× 前川, 聡× 扇田, 久和 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Diabetes mellitus (DM) causes injury to tissues and organs, including to the heart and kidney, resulting in increased morbidity and mortality. Thus, novel potential therapeutics are continuously required to minimize DM-related organ damage. We have previously shown that dipeptidyl peptidase III (DPPIII) has beneficial roles in a hypertensive mouse model, but it is unknown whether DPPIII has any effects on DM. In this study, we found that intravenous administration of recombinant DPPIII in diabetic db/db mice for eight weeks suppressed the DM-induced cardiac diastolic dysfunctions and renal injury without alteration of the blood glucose level. This treatment inhibited inflammatory cell infiltration and fibrosis in the heart, and blocked the increase in albuminuria by attenuating the disruption of the glomerular microvasculature and inhibiting the effacement of podocyte foot processes in the kidney. The beneficial role of DPPIII was, at least in part, mediated by the cleavage of a cytotoxic peptide, named Peptide 2, which was increased in db/db mice compared with normal mice. This peptide consisted of nine amino acids, was a digested fragment of complement component 3 (C3), and had an anaphylatoxin-like effect determined by the Miles assay and chemoattractant analysis. The effect was dependent on its interaction with the C3a receptor and protein kinase C-mediated RhoA activation downstream of the receptor in endothelial cells. In conclusion, DPPIII plays a protective role in the heart and kidney in a DM animal model through cleavage of a peptide that is a part of C3. | |||||
| 書誌情報 |
en : The Journal of biological chemistry 巻 296, 発行日 2021-05-07 |
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| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1083-351X | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33971198 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8167299/ | |||||
| 関連名称 | PMC8167299 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.jbc.2021.100761 | |||||
| 関連名称 | 10.1016/j.jbc.2021.100761 | |||||
| 権利 | ||||||
| 権利情報 | © 2021 The Authors. Published by Elsevier Inc. All rights reserved. | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
