導入化学療法にて根治切除が可能となった頸部食道癌の1例

MAEKAWA, Takeru; TAKEBAYASHI, Katsushi; KAIDA, Sachiko; YAMAGUCHI, Tsuyoshi; ISHIKAWA, Ken; IIDA, Hiroya; MIYAKE, Toru; UEKI, Tomoyuki; KOJIMA, Masatsugu; MAEHIRA, Hiromitsu; KODAMA, Hirokazu; TOKUDA, Aya; MORI, Haruki; YASUKAWA, Daiki; MURAMOTO, Keiji; FUKUO, Asuka; SHIMIZU, Tomoharu; MURATA, Satoshi; TANI, Masaji; 前川, 毅; 竹林, 克士; 貝田, 佐知子; 山口, 剛; 石川, 健; 飯田, 洋也; 三宅, 亨; 植木, 智之; 小島, 正継; 前平, 博充; 児玉, 泰一; 徳田, 彩; 森, 治樹; 安川, 大貴; 村本, 圭史; 福尾, 飛翔; 清水, 智治; 村田, 聡; 谷, 眞至

doi:http://doi.org/10.14999/1521.00012904

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1aであった．術後経過は概ね良好で術後9日目より経口摂取を開始し，術後18日目に退院となった．\n　切除不能局所進行食道癌に対する標準治療は化学放射線療法であるが，近年，DCF療法による導入化学療法後の外科的切除の有用性が報告されている．今回，導入化学療法により根治切除可能であった頸部食道癌，食道腺癌の重複例を経験したため報告する．", "subitem_description_type": "Abstract"}, {"subitem_description": "　A 58-year-old man with sore throat and dysphagia revealed type 3 lesion in cervical esophagus and 0-IIa+IIc lesion in esophagogastric junction on upper gastrointestinal endoscopy. Histopathologic examination of biopsy specimens showed squamous cell carcinoma at cervical esophagus and \nadenocarcinoma at esophagogastric junction. Computed tomography suggested that the large tumor in left neck infiltrated into the common carotid artery and trachea. According to these findings, we diagnosed locally advanced unresectable cervical esophageal cancer (cT4bN2M0, cStageIVa) and Barret’s esophageal adenocarcinoma (cT1bN0M0, cStageI), and decided to perform induction chemotherapy with Docetaxel, Cisplatin, and 5-Fluorouracil (DCF). After 3 courses of that, the primary tumor decreased from 37 mm to 17 mm as major axis and released infiltration into the common carotid artery. Therefore, we performed conversion surgery, pharyngolaryngectomy and total esophagectomy. Histopathological findings showed cervical esophageal cancer (ycT4aN2M0, ycStageIVa) and Barret’s esophageal adenocarcinoma (ycT1b-SM2N0M0, ycStageI). The postoperative course was uneventful, he resumed eating 9 days after surgery and was discharged 18 days after surgery.\n　Conversion surgery after induction chemotherapy for locally advanced unresectable esophageal cancer may contribute to radical resection and better clinical outcome.", "subitem_description_type": "Abstract"}]}, "item_3_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Departmental Bulletin Paper", "subitem_description_type": "Other"}]}, "item_3_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.14999/1521.00012904", "subitem_identifier_reg_type": "JaLC"}]}, "item_3_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "滋賀医科大学雑誌編集委員会"}]}, "item_3_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://doi.org/10.14999/1521.00012904"}], 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導入化学療法にて根治切除が可能となった頸部食道癌の1例

https://doi.org/10.14999/1521.00012904

名前 / ファイル	ライセンス	アクション
jsums3401p023 (784.6 kB)

Item type

紀要論文 / Departmental Bulletin Paper(1)

公開日

2021-02-09

タイトル

導入化学療法にて根治切除が可能となった頸部食道癌の1例

タイトル

言語

タイトル

A Case Report of Cervical Esophageal Cancer with Induction Chemotherapy Followed by Conversion Surgery

言語

jpn

キーワード

主題Scheme

Other

主題

頸部食道癌

キーワード

主題Scheme

Other

主題

導入化学療法

キーワード

主題Scheme

Other

主題

切除不能進行食道癌

キーワード

言語

主題Scheme

Other

主題

cervical esophageal cancer

キーワード

言語

主題Scheme

Other

主題

induction chemotherapy

キーワード

言語

主題Scheme

Other

主題

unresectable cancer

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_6501

資源タイプ

departmental bulletin paper

ID登録

10.14999/1521.00012904

ID登録タイプ

JaLC

タイトル（ヨミ）

その他のタイトル

ドウニュウカガクリョウホウニテコンチセツジョガカノウトナッタケイブショクドウガンノ 1レイ

著者

前川, 毅
竹林, 克士
貝田, 佐知子

WEKO 629
e-Rad 70710234
ORCID 0000-0002-1279-5942

	貝田, 佐知子

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山口, 剛

WEKO 627
e-Rad 10510290

	山口, 剛

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石川, 健
飯田, 洋也

WEKO 844
e-Rad 30733901
ORCID 0000-0001-6245-4583

	飯田, 洋也

Search repository

三宅, 亨

WEKO 812
e-Rad 70581924

	三宅, 亨

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植木, 智之

WEKO 811
ORCID 0000-0002-7285-5222

	植木, 智之

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小島, 正継

WEKO 3245
e-Rad 10452236

	小島, 正継

Search repository

前平, 博充

WEKO 6759
ORCID 0000-0003-3064-5216

	前平, 博充

Search repository

児玉, 泰一

WEKO 887
e-Rad 20581929

	児玉, 泰一

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徳田, 彩

WEKO 6933
e-Rad 80814392

	徳田, 彩

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森, 治樹

WEKO 6959
e-Rad 40803945

	森, 治樹

Search repository

安川, 大貴

WEKO 7505
e-Rad 80765074

	安川, 大貴

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村本, 圭史
福尾, 飛翔
清水, 智治

WEKO 268
e-Rad 70402708
ORCID 0000-0002-2858-0786

	清水, 智治

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村田, 聡

WEKO 210
e-Rad 90239525

	村田, 聡

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谷, 眞至

WEKO 696
e-Rad 60236677
ORCID 0000-0003-1270-6003

	谷, 眞至

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著者別名

MAEKAWA, Takeru

TAKEBAYASHI, Katsushi

KAIDA, Sachiko

WEKO 629
e-Rad 70710234
ORCID 0000-0002-1279-5942

	KAIDA, Sachiko

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YAMAGUCHI, Tsuyoshi

WEKO 627
e-Rad 10510290

	YAMAGUCHI, Tsuyoshi

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ISHIKAWA, Ken
IIDA, Hiroya

WEKO 844
e-Rad 30733901
ORCID 0000-0001-6245-4583

	IIDA, Hiroya

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MIYAKE, Toru

WEKO 812
e-Rad 70581924

	MIYAKE, Toru

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UEKI, Tomoyuki

WEKO 811
ORCID 0000-0002-7285-5222

	UEKI, Tomoyuki

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KOJIMA, Masatsugu

WEKO 3245
e-Rad 10452236

	KOJIMA, Masatsugu

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MAEHIRA, Hiromitsu

WEKO 6759
ORCID 0000-0003-3064-5216

	MAEHIRA, Hiromitsu

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KODAMA, Hirokazu

WEKO 887
e-Rad 20581929

	KODAMA, Hirokazu

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TOKUDA, Aya

WEKO 6933
e-Rad 80814392

	TOKUDA, Aya

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MORI, Haruki

WEKO 6959
e-Rad 40803945

	MORI, Haruki

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YASUKAWA, Daiki

WEKO 7505
e-Rad 80765074

	YASUKAWA, Daiki

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MURAMOTO, Keiji

FUKUO, Asuka
SHIMIZU, Tomoharu

WEKO 268
e-Rad 70402708
ORCID 0000-0002-2858-0786

	SHIMIZU, Tomoharu

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MURATA, Satoshi

WEKO 210
e-Rad 90239525

	MURATA, Satoshi

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TANI, Masaji

WEKO 696
e-Rad 60236677
ORCID 0000-0003-1270-6003

	TANI, Masaji

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内容記述タイプ

Abstract

内容記述

症例は50歳代，男性．咽頭痛，嚥下障害を主訴に近医受診し，上部消化管内視鏡検査にて頸部食道に1/4周性のtype3病変(squamous cell carcinoma)と食道胃接合部に0-IIa+IIc病変(adenocarcinoma)を指摘され，当院当科紹介となった．造影CT検査にて左頸部に原発巣と一塊となった腫瘤を認め，左総頸動脈及び気管への浸潤を認めた．精査の結果，頸部食道癌cT4bN2M0 cStageIVa，バレット食道腺癌cT1bN0M0 cStageIと診断し，切除不能局所進行食道癌であり導入化学療法の方針とした．DCF(Docetaxel/Cisplatin/5-Fluorouracil) 療法3コースで病変の縮小が得られ，頸部腫瘍は長径37mmから17mmとなり，総頸動脈の浸潤が解除されたため，根治術を行う方針とした．手術は咽頭喉頭食道全摘，頸部縦隔腹部リンパ節郭清，後縦隔経路遊離空腸付加胃管再建，腸瘻造設術を施行した．術中偶発症なく，手術時間846分，出血量670mLであった．病理組織学的検査では，頸部食道癌ypT4aN2M0 ypStegeIII，治療効果Grade 1b，バレット食道癌ypT1b-SM2N0M0 ypStageI，治療効果Grade 1aであった．術後経過は概ね良好で術後9日目より経口摂取を開始し，術後18日目に退院となった．
　切除不能局所進行食道癌に対する標準治療は化学放射線療法であるが，近年，DCF療法による導入化学療法後の外科的切除の有用性が報告されている．今回，導入化学療法により根治切除可能であった頸部食道癌，食道腺癌の重複例を経験したため報告する．

抄録

内容記述タイプ

Abstract

内容記述

A 58-year-old man with sore throat and dysphagia revealed type 3 lesion in cervical esophagus and 0-IIa+IIc lesion in esophagogastric junction on upper gastrointestinal endoscopy. Histopathologic examination of biopsy specimens showed squamous cell carcinoma at cervical esophagus and
adenocarcinoma at esophagogastric junction. Computed tomography suggested that the large tumor in left neck infiltrated into the common carotid artery and trachea. According to these findings, we diagnosed locally advanced unresectable cervical esophageal cancer (cT4bN2M0, cStageIVa) and Barret’s esophageal adenocarcinoma (cT1bN0M0, cStageI), and decided to perform induction chemotherapy with Docetaxel, Cisplatin, and 5-Fluorouracil (DCF). After 3 courses of that, the primary tumor decreased from 37 mm to 17 mm as major axis and released infiltration into the common carotid artery. Therefore, we performed conversion surgery, pharyngolaryngectomy and total esophagectomy. Histopathological findings showed cervical esophageal cancer (ycT4aN2M0, ycStageIVa) and Barret’s esophageal adenocarcinoma (ycT1b-SM2N0M0, ycStageI). The postoperative course was uneventful, he resumed eating 9 days after surgery and was discharged 18 days after surgery.
　Conversion surgery after induction chemotherapy for locally advanced unresectable esophageal cancer may contribute to radical resection and better clinical outcome.

書誌情報

滋賀医科大学雑誌

巻 34, 号 1, p. 23-26, 発行日 2021-02-09

出版者

滋賀医科大学雑誌編集委員会

DOI

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2023-06-19 11:14:26.272492

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導入化学療法にて根治切除が可能となった頸部食道癌の1例

× 前川, 毅

× 竹林, 克士

× 貝田, 佐知子

× 山口, 剛

× 石川, 健

× 飯田, 洋也

× 三宅, 亨

× 植木, 智之

× 小島, 正継

× 前平, 博充

× 児玉, 泰一

× 徳田, 彩

× 森, 治樹

× 安川, 大貴

× 村本, 圭史

× 福尾, 飛翔

× 清水, 智治

× 村田, 聡

× 谷, 眞至

× MAEKAWA, Takeru

× TAKEBAYASHI, Katsushi

× KAIDA, Sachiko

× YAMAGUCHI, Tsuyoshi

× ISHIKAWA, Ken

× IIDA, Hiroya

× MIYAKE, Toru

× UEKI, Tomoyuki

× KOJIMA, Masatsugu

× MAEHIRA, Hiromitsu

× KODAMA, Hirokazu

× TOKUDA, Aya

× MORI, Haruki

× YASUKAWA, Daiki

× MURAMOTO, Keiji

× FUKUO, Asuka

× SHIMIZU, Tomoharu

× MURATA, Satoshi

× TANI, Masaji

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