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Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation.
http://hdl.handle.net/10422/00012790
http://hdl.handle.net/10422/00012790887e8fb1-3069-4114-8c88-7ec0ab9d828d
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-09-11 | |||||
タイトル | ||||||
タイトル | Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ejaculation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Glutamate | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Lumbar spinothalamic (LSt) cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Lumbosacral spinal cord | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mGluR7 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
MASUGI-TOKITA, Miwako
× MASUGI-TOKITA, Miwako× TOMITA, Keiji× KOBAYASHI, Kenichi× YOSHIDA, Tetsuya× KAGEYAMA, Susumu× SAKAMOTO, Hirotaka× KAWAUCHI, Akihiro |
|||||
著者別名 |
馬杉, 美和子
× 馬杉, 美和子× 富田, 圭司× 小林, 憲市× 吉田, 哲也× 影山, 進× 河内, 明宏 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Metabotropic glutamate receptor subtype 7 (mGluR7) is a member of the group III mGluRs, which are negatively coupled to adenylate cyclase via Gi/Go proteins and localized to presynaptic active zones of the mammalian central nervous system (CNS). To elucidate the mechanism of impaired reproductivity of mGluR7 knockout (KO) mice, we investigated sexual behavior in this line, which exhibits ejaculatory disorder, although with normal sexual motivation and erectile function. To identify the site of action within the CNS responsible for the effect of mGluR7 on ejaculation, we then used a para-chloroamphetamine (PCA)-induced ejaculation model. Intrathecal administration of the mGluR7-selective antagonist 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP) into the lumbosacral spinal cord inhibited PCA-induced ejaculation. Immunohistochemistry revealed mGluR7-like immunoreactivity (LI) expressed in the same area where lumbar spinothalamic (LSt) cells regulate the parasympathetic ejaculatory pathway. At high magnification, the apposition of mGluR7-LI puncta and neuronal nitric oxide synthase (nNOS)-LI-positive putative parasympathetic preganglionic neurons was evident. These results indicate that mGluR7 in the lumbosacral spinal cord regulates ejaculation by potentiating the excitability of parasympathetic preganglionic neurons. The ejaculatory disorder is a major issue in the field of male reproductive function. Erectile dysfunction (ED) can be treated by phosphodiesterase type 5 inhibitors like sildenafil (Viagra®), but the ejaculatory disorder cannot. Lack of understanding of the ejaculatory mechanism hinders the development of therapies for ejaculatory problems. This study is the first to demonstrate that mGluR7 regulates ejaculation and the results provide insight into the mechanism of ejaculation as well as a strategy for future therapies to treat ejaculatory disorders in humans. | |||||
書誌情報 |
en : Molecular neurobiology 発行日 2020-08-31 |
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出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1559-1182 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32865662 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s12035-020-02090-2 | |||||
関連名称 | 10.1007/s12035-020-02090-2 | |||||
権利 | ||||||
権利情報 | ©Springer Science+Business Media, LLC, part of Springer Nature 2020 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |