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Although left ventricular end-diastolic pressure (LVEDP) is the gold standard of preload, the estimated trans left ventricular end-diastolic transmural pressure (eLVTMP) may be true preload especially in obese patients. ", "subitem_description_type": "Abstract"}, {"subitem_description": "Materials and methods:\nWe measured hemodynamic parameters and the plasma NT-proBNP level in the aortic root (AO) and coronary sinus (CS) in 602 left-sided heart disease patients. We defined normal as BMI \u003c 25 kg/m2 (n = 436), overweight as 25 ≤ BMI\u003c30 kg/m2 (n = 117), and obese as BMI ≥ 30 kg/m2 (n = 49). ", "subitem_description_type": "Abstract"}, {"subitem_description": "Results:\nThere were no significant differences in left ventricular ejection fraction (LVEF) or LVEDP among the three groups, and log (CSAO) NT-proBNP was significantly lower in overweight or obese patients than in normal patients. From stepwise multivariate analyses, eLVTMP (eLVTMP = LVEDPright atrial pressure), LVEF, and BMI were independent predictors of log (CSAO) NT-proBNP, but LVEDP was not. The eLVTMP was significantly lower in obese patients than in overweight patients (7.5 ± 5.1 vs. 9.6 ± 5.3 mmHg, p \u003c 0.05) or normal patients (7.5 ± 5.1 vs. 9.6 ± 4.7 mmHg, p \u003c 0.01). ", "subitem_description_type": "Abstract"}, {"subitem_description": "Conclusion:\nLower eLVTMP, as a marker of left ventricular preload, may contribute to the lower NT-proBNP secretion from the heart in obese patients. 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Relationship between left ventricular preload and N-terminal pro-brain natriuretic peptide in obese patients.
http://hdl.handle.net/10422/00012763
http://hdl.handle.net/10422/00012763fb4bb33a-7dcb-432f-ab46-5ce51d83cd6a
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-07-27 | |||||
タイトル | ||||||
タイトル | Relationship between left ventricular preload and N-terminal pro-brain natriuretic peptide in obese patients. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Body mass index | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hemodynamics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | N-terminal pro-brain natriuretic peptide | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Obesity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Preload. | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
TSUTAMOTO, Takayoshi
× TSUTAMOTO, Takayoshi× SAKAI, Hiroshi× YAMAMOTO, Takashi× NAKAGAWA, Yoshihisa |
|||||
著者別名 |
蔦本, 尚慶
× 蔦本, 尚慶× 酒井, 宏× 山本, 孝× 中川, 義久 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The reason for low plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with a high body mass index (BMI) is unknown. Although left ventricular end-diastolic pressure (LVEDP) is the gold standard of preload, the estimated trans left ventricular end-diastolic transmural pressure (eLVTMP) may be true preload especially in obese patients. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Materials and methods: We measured hemodynamic parameters and the plasma NT-proBNP level in the aortic root (AO) and coronary sinus (CS) in 602 left-sided heart disease patients. We defined normal as BMI < 25 kg/m2 (n = 436), overweight as 25 ≤ BMI<30 kg/m2 (n = 117), and obese as BMI ≥ 30 kg/m2 (n = 49). |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: There were no significant differences in left ventricular ejection fraction (LVEF) or LVEDP among the three groups, and log (CSAO) NT-proBNP was significantly lower in overweight or obese patients than in normal patients. From stepwise multivariate analyses, eLVTMP (eLVTMP = LVEDPright atrial pressure), LVEF, and BMI were independent predictors of log (CSAO) NT-proBNP, but LVEDP was not. The eLVTMP was significantly lower in obese patients than in overweight patients (7.5 ± 5.1 vs. 9.6 ± 5.3 mmHg, p < 0.05) or normal patients (7.5 ± 5.1 vs. 9.6 ± 4.7 mmHg, p < 0.01). |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: Lower eLVTMP, as a marker of left ventricular preload, may contribute to the lower NT-proBNP secretion from the heart in obese patients. |
|||||
書誌情報 |
en : Journal of cardiology 巻 S0914-5087, 号 20, p. 30226-4, 発行日 2020-07-15 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1876-4738 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32682625 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.jjcc.2020.07.004 | |||||
関連名称 | 10.1016/j.jjcc.2020.07.004 | |||||
権利 | ||||||
権利情報 | © 2020. Published by Elsevier Ltd. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |