{"_buckets": {"deposit": "8e752a8d-d919-4789-bcd3-6c010922efd5"}, "_deposit": {"created_by": 11, "id": "3489", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "3489"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00003489", "sets": ["228"]}, "author_link": ["7694", "7693", "706", "7253", "7638", "644", "7639", "7509"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-01-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "417", "bibliographicPageStart": "408", "bibliographicVolumeNumber": "55", "bibliographic_titles": [{}, {"bibliographic_title": "Journal of gastroenterology", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "杉谷, 義彦"}], "nameIdentifiers": [{"nameIdentifier": "7693", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "西田, 淳史"}], "nameIdentifiers": [{"nameIdentifier": "7639", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90719915", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90719915"}, {"nameIdentifier": "0000-0002-1288-3272", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-1288-3272"}]}, {"creatorNames": [{"creatorName": "稲富, 理"}], "nameIdentifiers": [{"nameIdentifier": "706", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70530351", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70530351"}, {"nameIdentifier": "0000-0002-5837-6575", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-5837-6575"}]}, {"creatorNames": [{"creatorName": "大野, 将司"}], "nameIdentifiers": [{"nameIdentifier": "7253", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80845488", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80845488"}, {"nameIdentifier": "0000-0003-3505-7835", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-3505-7835"}]}, {"creatorNames": [{"creatorName": "今井, 隆行"}], "nameIdentifiers": [{"nameIdentifier": "7638", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "0000-0002-9170-4075", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-9170-4075"}]}, {"creatorNames": [{"creatorName": "河原, 真大"}], "nameIdentifiers": [{"nameIdentifier": "7509", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80617449", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80617449"}, {"nameIdentifier": "0000-0002-2721-7571", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-2721-7571"}]}, {"creatorNames": [{"creatorName": "安藤, 朗"}], "nameIdentifiers": [{"nameIdentifier": "644", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252395"}, {"nameIdentifier": "0000-0001-8533-2669", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8533-2669"}]}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "BACKGROUND:\nProstasin (PRSS8) is a stimulator of epithelial sodium transport. In this study, we evaluated alteration of prostasin expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and investigated the role of prostasin in the gut inflammation.", "subitem_description_type": "Abstract"}, {"subitem_description": "METHODS:\nProstasin expression was evaluated by immunohistochemical staining. Dextran sodium sulfate (DSS)-colitis was induced in mice lacking prostasin specifically in intestinal epithelial cells (PRSS8ΔIEC mice).", "subitem_description_type": "Abstract"}, {"subitem_description": "RESULTS:\nIn colonic mucosa of healthy individuals, prostasin was strongly expressed at the apical surfaces of epithelial cells, and this was markedly decreased in active mucosa of both ulcerative colitis and Crohn\u0027s disease. DSS-colitis was exacerbated in PRSS8ΔIEC mice compared to control PRSS8lox/lox mice. Toll-like receptor4 (TLR4) expression in colonic epithelial cells was stronger in DSS-treated PRSS8ΔIEC mice than in DSS-treated PRSS8 lox/lox mice. NF-κB activation in colonic epithelial cells was more pronounced in DSS-treated PRSS8ΔIEC mice than in DSS-treated PRSS8lox/lox mice, and the mRNA expression of inflammatory cytokines was significantly higher in DSS-treated PRSS8ΔIEC mice. Broad-spectrum antibiotic treatment completely suppressed the exacerbation of DSS-colitis in PRSS8ΔIEC mice. The mRNA expression of tight junction proteins and mucosal permeability assessed using FITC-dextran were comparable between DSS-treated PRSS8lox/lox and DSS-treated PRSS8ΔIEC mice.", "subitem_description_type": "Abstract"}, {"subitem_description": "CONCLUSION:\nProstasin has an anti-inflammatory effect via downregulation of TLR4 expression in colonic epithelial cells. Reduced prostasin expression in IBD mucosa is linked to the deterioration of local anti-inflammatory activity and may contribute to the persistence of mucosal inflammation.", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer International"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "31916038", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00535-019-01660-z"}], "subitem_relation_type": "isVersionOf", "subitem_relation_type_id": 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"OHNO, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "7253", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80845488", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80845488"}, {"nameIdentifier": "0000-0003-3505-7835", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-3505-7835"}]}, {"creatorNames": [{"creatorName": "IMAI, Takayuki"}], "nameIdentifiers": [{"nameIdentifier": "7638", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "0000-0002-9170-4075", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-9170-4075"}]}, {"creatorNames": [{"creatorName": "KAWAHARA, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "7509", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80617449", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80617449"}, {"nameIdentifier": "0000-0002-2721-7571", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-2721-7571"}]}, {"creatorNames": [{"creatorName": "KITAMURA, Kenichiro"}], "nameIdentifiers": [{"nameIdentifier": "7694", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ANDOH, Akira"}], "nameIdentifiers": [{"nameIdentifier": "644", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252395"}, {"nameIdentifier": "0000-0001-8533-2669", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8533-2669"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-01-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "s00535-019-01660-z.pdf", "filesize": [{"value": "251.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© Japanese Society of Gastroenterology 2020", "licensetype": "license_free", "mimetype": "application/pdf", "size": 251900.0, "url": {"label": "s00535-019-01660-z", "url": "https://shiga-med.repo.nii.ac.jp/record/3489/files/s00535-019-01660-z.pdf"}, "version_id": "2d8581ff-b749-472c-b32e-a52e4cf8de83"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Mucosal permeability", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NF-κB", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Prostasin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TLR4", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", 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