{"_buckets": {"deposit": "01e38c79-0ceb-4878-8776-76e429e241b7"}, "_deposit": {"created_by": 11, "id": "3291", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "3291"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00003291", "sets": ["205"]}, "author_link": ["1985", "268", "811", "7601", "696", "6933", "464", "812", "6766"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-07-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "51", "bibliographicPageEnd": "29586", "bibliographicPageStart": "29574", "bibliographicVolumeNumber": "9", "bibliographic_titles": [{"bibliographic_title": "Oncotarget"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "生田, 大二"}], "nameIdentifiers": [{"nameIdentifier": "6766", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00581935", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00581935"}]}, {"creatorNames": [{"creatorName": "三宅, 亨"}], "nameIdentifiers": [{"nameIdentifier": "812", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70581924", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70581924"}]}, {"creatorNames": [{"creatorName": "清水, 智治"}], "nameIdentifiers": [{"nameIdentifier": "268", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70402708", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70402708"}, {"nameIdentifier": "0000-0002-2858-0786", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-2858-0786"}]}, {"creatorNames": [{"creatorName": "園田, 寛道"}], "nameIdentifiers": [{"nameIdentifier": "464", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80437152", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80437152"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "向所, 賢一", "creatorNameLang": ""}, {"creatorName": "向所, 賢一", "creatorNameLang": ""}, {"creatorName": "向所, 賢一", "creatorNameLang": ""}, {"creatorName": "MUKAISHO, Ken-ichi", "creatorNameLang": "en"}, {"creatorName": "向所, 賢一", "creatorNameLang": "ja"}, {"creatorName": "ムカイショ, ケンイチ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "向所", "familyNameLang": ""}, {"familyName": "向所", "familyNameLang": ""}, {"familyName": "向所", "familyNameLang": ""}, {"familyName": "MUKAISHO", "familyNameLang": "en"}, {"familyName": "向所", "familyNameLang": "ja"}, {"familyName": "ムカイショ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "賢一", "givenNameLang": ""}, {"givenName": "賢一", "givenNameLang": ""}, {"givenName": "賢一", "givenNameLang": ""}, {"givenName": "Ken-ichi", "givenNameLang": "en"}, {"givenName": "賢一", "givenNameLang": "ja"}, {"givenName": "ケンイチ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1985", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50343223", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50343223"}, {"nameIdentifier": "0000-0002-0488-0100", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-0488-0100"}]}, {"creatorNames": [{"creatorName": "徳田, 彩"}], "nameIdentifiers": [{"nameIdentifier": "6933", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80814392", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80814392"}]}, {"creatorNames": [{"creatorName": "植木, 智之"}], "nameIdentifiers": [{"nameIdentifier": "811", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "0000-0002-7285-5222", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-7285-5222"}]}, {"creatorNames": [{"creatorName": "谷, 眞至"}], "nameIdentifiers": [{"nameIdentifier": "696", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60236677", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60236677"}, {"nameIdentifier": "0000-0003-1270-6003", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-1270-6003"}]}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background:\nTumor microenvironment including fibrosis has a pivotal role in cancer growth and distant metastasis. Fibrosis is a known risk factor for carcinogenesis, but its \nbiological role in disease invasion and metastasis in colorectal cancer (CRC) remains \nunclear. In particular, there is no report on how fibrosis of metastatic lymph nodes\n(MLNs) in CRC contributes to prognosis.", "subitem_description_type": "Abstract"}, {"subitem_description": "Methods:\nWe reviewed 94 colorectal adenocarcinoma patients with MLNs who underwent\ncolectomy. Both the primary tumors and MLNs were analyzed for alpha-smooth muscle\nactin (α-SMA) expression and collagen deposition.", "subitem_description_type": "Abstract"}, {"subitem_description": "Results:\nHigher α-SMA expression and collagen deposition in MLNs were associated with\nsignificantly shorter relapse-free survival and overall survival in CRC patients. α-SMA \nexpression in MLNs (HR, 1.53; p = 0.034) was independent predictive factor of overall\nsurvival in multivariate Cox proportional hazards regression analysis of clinicopathological\nfactors. In the Stage III patient subgroup, α-SMA expression in MLNs was a strong \nprognostic marker (HR, 3.01; p = 0.006). On the other hand, higher α-SMA expression\nand collagen deposition in primary tumors were associated with short overall survival, \nbut they were not significant factors in multivariate Cox regression analyses. In MLNs,\nthe podoplanin signals co-localized with α-SMA expression and were confirmed by the\ndual immunofluorescence staining, implying that the MLN stromal cells were fibroblastic\nreticular cells.", "subitem_description_type": "Abstract"}, {"subitem_description": "Conclusion:\nBoth high collagen deposition and high α-SMA expression in MLNs predicted poor \nprognosis in CRC.", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Impact Journals"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "30038705", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.18632/oncotarget.25636", "subitem_relation_type_select": "DOI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "\tAll site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License"}]}, "item_4_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1949-2553", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "生田, 大二"}], "nameIdentifiers": [{"nameIdentifier": "6766", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00581935", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00581935"}]}, {"creatorNames": [{"creatorName": "MIYAKE, Toru"}], "nameIdentifiers": [{"nameIdentifier": "812", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70581924", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70581924"}]}, {"creatorNames": [{"creatorName": "SHIMIZU, Tomoharu"}], "nameIdentifiers": [{"nameIdentifier": "268", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70402708", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70402708"}, {"nameIdentifier": "0000-0002-2858-0786", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-2858-0786"}]}, {"creatorNames": [{"creatorName": "SONODA, Hiromichi"}], "nameIdentifiers": [{"nameIdentifier": "464", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80437152", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80437152"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "向所, 賢一", "creatorNameLang": ""}, {"creatorName": "向所, 賢一", "creatorNameLang": ""}, {"creatorName": "向所, 賢一", "creatorNameLang": ""}, {"creatorName": "MUKAISHO, Ken-ichi", "creatorNameLang": "en"}, {"creatorName": "向所, 賢一", "creatorNameLang": "ja"}, {"creatorName": "ムカイショ, ケンイチ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "向所", "familyNameLang": ""}, {"familyName": "向所", "familyNameLang": ""}, {"familyName": "向所", "familyNameLang": ""}, {"familyName": "MUKAISHO", "familyNameLang": "en"}, {"familyName": "向所", "familyNameLang": "ja"}, {"familyName": "ムカイショ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "賢一", "givenNameLang": ""}, {"givenName": "賢一", "givenNameLang": ""}, {"givenName": "賢一", "givenNameLang": ""}, {"givenName": "Ken-ichi", "givenNameLang": "en"}, {"givenName": "賢一", "givenNameLang": "ja"}, {"givenName": "ケンイチ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1985", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50343223", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50343223"}, {"nameIdentifier": "0000-0002-0488-0100", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-0488-0100"}]}, {"creatorNames": [{"creatorName": "Tokuda, Aya"}], "nameIdentifiers": [{"nameIdentifier": "6933", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80814392", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80814392"}]}, {"creatorNames": [{"creatorName": "Ueki, Tomoyuki"}], "nameIdentifiers": [{"nameIdentifier": "811", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "0000-0002-7285-5222", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-7285-5222"}]}, {"creatorNames": [{"creatorName": "SUGIHARA, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "7601", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30171169", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30171169"}]}, {"creatorNames": [{"creatorName": "TANI, Masaji"}], "nameIdentifiers": [{"nameIdentifier": "696", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60236677", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60236677"}, {"nameIdentifier": "0000-0003-1270-6003", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-1270-6003"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-08-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "oncotarget.25636.pdf", "filesize": [{"value": "6.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0(CC BY 3.0), which permits unrestricted use, \ndistribution, and reproduction in any medium, provided the original author and\nsource are credited.", "licensetype": "license_free", "mimetype": "application/pdf", "size": 6700000.0, "url": {"label": "oncotarget.25636", "url": "https://shiga-med.repo.nii.ac.jp/record/3291/files/oncotarget.25636.pdf"}, "version_id": "3b9a6198-cc90-4deb-a0a1-8c15390bd307"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "cancer-associated fibroblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "colorectal cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fibroblastic reticular cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fibrosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lymph node metastasis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer."}]}, "item_type_id": "4", "owner": "11", "path": ["205"], "permalink_uri": "http://hdl.handle.net/10422/00012429", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-08-10"}, "publish_date": "2018-08-10", "publish_status": "0", "recid": "3291", "relation": {}, "relation_version_is_last": true, "title": ["Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer."], "weko_shared_id": -1}