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Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer.
http://hdl.handle.net/10422/00012429
http://hdl.handle.net/10422/0001242940d3a9ec-beb0-4eed-aad9-33e9d57e716d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
oncotarget.25636 (6.7 MB)
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This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0(CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-08-10 | |||||
| タイトル | ||||||
| タイトル | Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cancer-associated fibroblast | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | colorectal cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | fibroblastic reticular cell | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | fibrosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | lymph node metastasis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
IKUTA, Daiji
× IKUTA, Daiji× MIYAKE, Toru× SHIMIZU, Tomoharu× SONODA, Hiromichi× MUKAISHO, Ken-ichi× Tokuda, Aya× UEKI, Tomoyuki× SUGIHARA, Hiroyuki× TANI, Masaji |
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| 著者別名 |
生田, 大二
× 生田, 大二× 三宅, 亨× 清水, 智治× 園田, 寛道× 向所, 賢一× 徳田, 彩× 植木, 智之× 杉原, 洋行× 谷, 眞至 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Tumor microenvironment including fibrosis has a pivotal role in cancer growth and distant metastasis. Fibrosis is a known risk factor for carcinogenesis, but its biological role in disease invasion and metastasis in colorectal cancer (CRC) remains unclear. In particular, there is no report on how fibrosis of metastatic lymph nodes (MLNs) in CRC contributes to prognosis. Methods: We reviewed 94 colorectal adenocarcinoma patients with MLNs who underwent colectomy. Both the primary tumors and MLNs were analyzed for alpha-smooth muscle actin (α-SMA) expression and collagen deposition. Results: Higher α-SMA expression and collagen deposition in MLNs were associated with significantly shorter relapse-free survival and overall survival in CRC patients. α-SMA expression in MLNs (HR, 1.53; p = 0.034) was independent predictive factor of overall survival in multivariate Cox proportional hazards regression analysis of clinicopathological factors. In the Stage III patient subgroup, α-SMA expression in MLNs was a strong prognostic marker (HR, 3.01; p = 0.006). On the other hand, higher α-SMA expression and collagen deposition in primary tumors were associated with short overall survival, but they were not significant factors in multivariate Cox regression analyses. In MLNs, the podoplanin signals co-localized with α-SMA expression and were confirmed by the dual immunofluorescence staining, implying that the MLN stromal cells were fibroblastic reticular cells. Conclusion: Both high collagen deposition and high α-SMA expression in MLNs predicted poor prognosis in CRC. |
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| 言語 | en | |||||
| 書誌情報 |
en : Oncotarget 巻 9, 号 51, p. 29574-29586, 発行日 2018-07-03 |
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| 出版者 | ||||||
| 出版者 | Impact Journals | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1949-2553 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30038705 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.18632/oncotarget.25636 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
