{"_buckets": {"deposit": "e4930321-84ae-40a7-b62b-495a72f9f0fe"}, "_deposit": {"created_by": 11, "id": "2890", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "2890"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00002890", "sets": ["37"]}, "author_link": [], "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-01-16", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "142", "bibliographicPageStart": "134", "bibliographicVolumeNumber": "106", "bibliographic_titles": [{"bibliographic_title": "Cancer science", "bibliographic_titleLang": "en"}]}]}, "item_6_date_granted_70": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2015-03-10"}]}, "item_6_degree_grantor_68": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "滋賀医科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "14202", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_6_degree_name_67": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）", "subitem_degreename_language": "ja"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Given the close interaction between tumor cells and stromal cells in the tumor microenvironment (TME), TME-targeted strategies would be promising for developing integrated cancer immunotherapy. Cancer-associated fibroblasts (CAFs) are the dominant stromal component, playing critical roles in generation of the pro-tumorigenic TME. We focused on the immunosuppressive trait of CAFs, and systematically explored the alteration of tumor-associated immune responses by CAF-targeted therapy. C57BL/6 mice s.c. bearing syngeneic E.G7 lymphoma, LLC1 Lewis lung cancer, or B16F1 melanoma were treated with an anti-fibrotic agent, tranilast, to inhibit CAF function. The infiltration of immune suppressor cell types, including regulatory T cells and myeloid-derived suppressor cells, in the TME was effectively decreased through reduction of stromal cell-derived factor-1, prostaglandin E2 , and transforming growth factor-β. In tumor-draining lymph nodes, these immune suppressor cell types were significantly decreased, leading to activation of tumor-associated antigen-specific CD8(+) T cells. In addition, CAF-targeted therapy synergistically enhanced multiple types of systemic antitumor immune responses such as the cytotoxic CD8(+) T cell response, natural killer activity, and antitumor humoral immunity in combination with dendritic cell-based vaccines; however, the suppressive effect on tumor growth was not observed in tumor-bearing SCID mice. These data indicate that systemic antitumor immune responses by various immunologic cell types are required to bring out the efficacy of CAF-targeted therapy, and these effects are enhanced when combined with effector-stimulatory immunotherapy such as dendritic cell-based vaccines. Our mouse model provides a novel rationale with TME-targeted strategy for the development of cell-based cancer immunotherapy. 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Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. "}]}, "item_6_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1347-9032", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11808050", "subitem_source_identifier_type": "NCID"}]}, "item_6_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "OHSHIO, Yasuhiko", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "cas12584.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "cas12584.pdf", "objectType": "fulltext", "url": "https://shiga-med.repo.nii.ac.jp/record/2890/files/cas12584.pdf"}, "version_id": "eb013fa1-bf45-4537-93ad-54645c41c6b2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cancer-associated fibroblasts", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dendritic cell-based vaccine immunotherapy", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "suppressor immune cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tranilast", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumor microenvironment", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in the dendritic cell-based vaccine.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in the dendritic cell-based vaccine.", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "11", "path": ["37"], "permalink_uri": "http://hdl.handle.net/10422/10591", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2015-07-24"}, "publish_date": "2015-07-24", "publish_status": "0", "recid": "2890", "relation": {}, "relation_version_is_last": true, "title": ["Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in the dendritic cell-based vaccine."], "weko_shared_id": -1}