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Exploratory study on quantitative assessment of skin hardness in patients with systemic sclerosis using SOFTGRAM
http://hdl.handle.net/10422/0002000472
http://hdl.handle.net/10422/0002000472d3cccc50-0ffd-4c39-9523-0a6525382915
Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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公開日 | 2025-06-17 | |||||||||
タイトル | ||||||||||
タイトル | Exploratory study on quantitative assessment of skin hardness in patients with systemic sclerosis using SOFTGRAM | |||||||||
言語 | en | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | modified Rodnan’s total skin thickness score | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | skin hardness | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | systemic sclerosis | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
資源タイプ | doctoral thesis | |||||||||
アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
著者 |
KOKUBU, Hiraku
× KOKUBU, Hiraku |
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著者別名 |
國府, 拓
× 國府, 拓
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | OBJECTIVES: There is a lack of quantitative and objective methods for measuring skin hardness. This study aimed to verify whether SOFTGRAM, a device that can measure elastic modulus using the Hertz elastic contact theory, could be used to evaluate skin hardness in systemic sclerosis (SSc). METHODS: Skin score according to the modified Rodnan total skin thickness score and elastic modulus of the skin using SOFTGRAM were measured for 20 patients with SSc and 20 healthy controls on 8 parts of the body, both of the cheeks, forearms, fingers, and hands. Five observers shared to measure skin score 320 times (40 participants × 8 parts). Elastic modulus was measured 1600 times (40 participants × 8 parts × 5 times each). As an additional examination to compare differences between observers, the skin score of another healthy control was measured 40 times (5 observers × 8 parts). Elastic modulus was measured 200 times (5 observers × 8 parts × 5 times each). RESULTS: There was a significant correlation between elastic modulus and skin score (correlation coefficient=0.67, p<0.001) and a significant difference in elastic modulus (8 parts: healthy controls vs. limited cutaneous SSc vs. diffuse cutaneous SSc: 22.6±15.7 vs. 32.0±27.7 vs. 44.8±39.8, p<0.001). Intraobserver reliabilities were sufficient in 6 out of 7 observers; however, interobserver was less satisfactory. CONCLUSIONS: This study showed the practicality of SOFTGRAM as an accurate measurement method of skin hardness but also revealed points to be improved. More studies are needed to find an accurate measurement method of skin hardness. |
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言語 | en | |||||||||
学位名 | ||||||||||
言語 | ja | |||||||||
学位名 | 博士(医学) | |||||||||
学位授与機関 | ||||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||
学位授与機関識別子 | 14202 | |||||||||
言語 | ja | |||||||||
学位授与機関名 | 滋賀医科大学 | |||||||||
学位授与年度 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 令和6年度 | |||||||||
言語 | ja | |||||||||
学位授与年月日 | ||||||||||
学位授与年月日 | 2025-03-21 | |||||||||
学位授与番号 | ||||||||||
学位授与番号 | 甲第1017号 | |||||||||
書誌情報 |
en : Clinical and Experimental Rheumatology 巻 42, 号 8, p. 1549-1555, 発行日 2024-08-13 |
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出版者 | ||||||||||
出版者 | Clinical And Experimental Rheumatology S.A.S | |||||||||
言語 | en | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | © Clinical and Experimental Rheumatology 2024. | |||||||||
著者版フラグ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0392-856X | |||||||||
PMID | ||||||||||
識別子タイプ | PMID | |||||||||
関連識別子 | 37933582 | |||||||||
DOI | ||||||||||
関連タイプ | isIdenticalTo | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.55563/clinexprheumatol/6z4e7m | |||||||||
関係URI | ||||||||||
識別子タイプ | HDL | |||||||||
関連識別子 | http://hdl.handle.net/10422/0002000438 | |||||||||
言語 | ja | |||||||||
関連名称 | 学位論文要旨 |