Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2024-04-24 |
タイトル |
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言語 |
en |
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タイトル |
Development of new bioabsorbable implants with de novo adipogenesis |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Bioabsorbable implant |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Adipogenesis |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Breast reconstruction |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
PGA nano sheet |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
PLLA |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Collagen sponge |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
著者 |
ZHAO, Qiannan
OGINO, Shuichi
LEE, Sunghee
KATO, Yuki
LI, Yuanjiaozi
SAKAMOTO, Michiharu
YAMANAKA, Hiroki
NAKANO, Takashi
SAWARAGI, Eiichi
MORIMOTO, Naoki
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著者別名 |
荻野, 秀一
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Poly-L-lactic acid (PLLA) mesh implants containing collagen sponge (CS) were replaced with autologous adipose tissue regeneration in vivo. Herein, we investigated the optimal external frames and internal fillings using poly (lactic-co-ε-caprolactone) (P (LA/CL)), PLLA, and low-molecular-weight PLLA (LMW-PLLA) as the external frame and polyglycolic acid (PGA) nanosheets and CS as the internal filling. We prepared six implants: P (LA/CL) with PGA nano, PLLA with PGA nano, PLLA with CS, PLLA with 1/2 CS, PLLA with 1/4 CS, and LMW-PLLA with CS, and evaluated adipogenesis at 6 and 12 months using a rat inguinal model. The internal spaces in the P (LA/CL) and LMW-PLLA implants collapsed at 6 months, whereas those in the other four implants collapsed at 12 months. Adipose tissue regeneration was not significantly different between the PLLA-implanted groups at 6 and 12 months and was greater than that in the P (LA/CL) with PGA nano and LMW-PLLA with CS groups. The PGA nanosheet inside PLLA was comparable to the CS inside PLLA in the regeneration of adipose tissue and macrophage infiltration. In summary, PLLA is a promising external frame material in which the internal space can be replaced with adipose tissue. Thus, PGA nanosheets are an alternative internal filling material for adipose tissue regeneration. |
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言語 |
en |
書誌情報 |
en : Regenerative Therapy
巻 24,
p. 311-317,
発行日 2023-08-12
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出版者 |
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言語 |
en |
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出版者 |
Japanese Society of Regenerative Medicine |
ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2352-3204 |
PMID |
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識別子タイプ |
PMID |
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関連識別子 |
37638279 |
PMCID |
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関連タイプ |
isIdenticalTo |
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言語 |
en |
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関連名称 |
PMC10448420 |
DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.reth.2023.07.008 |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |