Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model.

ARAKI, Susumu

doi:https://doi.org/10.3109/17453674.2014.958807

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Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model.

http://hdl.handle.net/10422/10491

名前 / ファイル	ライセンス	アクション
17453674%2E2014%2E958807.pdf (4.0 MB)

Item type

学位論文 / Thesis or Dissertation(1)

公開日

2015-07-15

タイトル

Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model.

言語

eng

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_db06

資源タイプ

doctoral thesis

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

著者

ARAKI, Susumu

抄録

内容記述タイプ

Abstract

内容記述

Background and purpose:
Integration of repaired cartilage with surrounding native cartilage is a major challenge for successful tissue-engineering strategies of cartilage repair. We investigated whether incorporation of mesenchymal stem cells (MSCs) into the collagen scaffold improves integration and repair of cartilage defects in a cynomolgus macaque model.

言語

抄録

内容記述タイプ

Abstract

内容記述

Methods:
Cynomolgus macaque bone marrow-derived MSCs were isolated and incorporated into type-I collagen gel. Full-thickness osteochondral defects (3 mm in diameter, 5 mm in depth) were created in the patellar groove of 36 knees of 18 macaques and were either left untreated (null group, n = 12), had collagen gel alone inserted (gel group, n = 12), or had collagen gel incorporating MSCs inserted (MSC group, n = 12). After 6, 12, and 24 weeks, the cartilage integration and tissue response were evaluated macroscopically and histologically (4 null, 4 gel, and 4 MSC knees at each time point).

言語

抄録

内容記述タイプ

Abstract

内容記述

Results:
The gel group showed most cartilage-rich reparative tissue covering the defect, owing to formation of excessive cartilage extruding though the insufficient subchondral bone. Despite the fact that a lower amount of new cartilage was produced, the MSC group had better-quality cartilage with regular surface, seamless integration with neighboring naïve cartilage, and reconstruction of trabecular subchondral bone.

言語

抄録

内容記述タイプ

Abstract

内容記述

Interpretation:
Even with intensive investigation, MSC-based cell therapy has not yet been established in experimental cartilage repair. Our model using cynomolgus macaques had optimized conditions, and the method using MSCs is superior to other experimental settings, allowing the possibility that the procedure might be introduced to future clinical practice.

言語

学位名

言語

学位名

博士（医学）

学位授与機関

学位授与機関識別子Scheme

kakenhi

学位授与機関識別子

14202

言語

学位授与機関名

滋賀医科大学

学位授与年度

内容記述タイプ

Other

内容記述

平成26年度

言語

学位授与年月日

2014-09-10

学位授与番号

乙第410号

書誌情報

en : Acta Orthopaedica

巻 86, 号 1, p. 119-126, 発行日 2015-02

出版者

Informa Healthcare

言語

著者版フラグ

出版タイプResource

http://purl.org/coar/version/c_970fb48d4fbd8a85

ISSN

収録物識別子タイプ

PISSN

収録物識別子

1745-3674

PMID

識別子タイプ

PMID

Versions

Ver.1

2023-06-19 12:10:13.428880

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Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model.

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